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Gastrointestinal stromal tumor of the posterior mediastinum |
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| Authors: | Jeffrey R. Lee Mark P. Anstadt Shamsuddin Khwaja Linda K. Green |
| Affiliation: | a Veterans Affairs Medical Center, Institute of Molecular Medicine and Genetics and Department of Pathology, Medical College of Georgia, Augusta, GA, USA b Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Georgia, Augusta, GA, USA c Department of Surgery, Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA d Department of Pathology, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA |
| Abstract: | Gastrointestinal stromal tumor (GIST) is a rare, but potentially aggressive tumor. We present an asymptomatic 64-year-old man with an incidental 9-cm GIST that arose in the posterior mediastinum. Wide surgical excision was performed with rotation of an intercostal muscle flap to buttress a surgically created esophageal wall defect. The patient is now free of disease 26 months postoperative. This tumor is defined by the carcinogenic over-expression of KIT-protein, a tyrosine kinase receptor. Accurate diagnosis of gastrointestinal stromal tumor is imperative, as specific medical therapy is now available for potential control of recurrent or metastatic disease. |
| Keywords: | Gastrointestinal stromal tumor (GIST) Gastrointestinal autonomic nerve tumor (GANT) KIT Mediastinum Esophagus |
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