102例患者静脉应用唑来膦酸注射液的临床安全性观察

目的:通过对102例患者静脉应用唑来膦酸注射液的病例资料调研,观察该药的临床安全性。方法:采用回顾性研究方法,对我院2011年12月-2013年12月期间使用唑来膦酸注射液的患者情况及药物不良反应进行了统计和分析。结果:不良反应以发热最为常见,发生率为71.5%,其次是低血钙、低血磷,全部不良反应均为一过性反应,无严重不良反应发生。结论:唑来膦酸的不良反应发生率高,临床使用中应严密观察患者,一旦发热应积极给予退热治疗,同时监测血钙、磷、钾、镁、铁、肌酐和血常规,以减少不良反应对患者的影响。

Safety Observation on 102 Cases with Zoledronic Acid Injection

Objective： To evaluate the clinical safety of zoledronic acid injection by analyzing 102 cases of patients with intravenous zoledronic acid injection. Methods： Based on retrospective study in our hospital from December 2011 to December 2013, the adverse reactions of patients who used zoledronic acid injection were made analyzed statistical y. Results： the adverse reaction of fever was the most common, the incidence rate was 71.5%, fol owed by hypocalcemia, hypophosphatemia, and al the adverse effects were transient response, no serious adverse reactions reported. Conclusion： adverse reactions with zoledronic acid were very common which should be given more attention, and calcium, phosphorus, magnesium, potassium, iron, creatinine, blood routine monitoring should also be monitored in the patients treated with Zoledronic Acid.