补充维生素D对COPD患者骨密度及炎症因子的影响

目的:探讨补充维生素D对慢性阻塞性肺疾病(COPD)患者骨密度及炎症因子的影响。方法:将维生素D缺乏的COPD患者随机分成观察组175例和对照组175例,两组常规治疗相同,观察组加用骨化三醇胶丸(0.25μg·d-1)治疗,比较两组治疗3个月后骨密度、炎症因子及肺功能的差别。结果:1治疗后,观察组血钙、25(OH)D、骨密度和T值均显著高于对照组,血磷、TNF-α和IL-6均显著低于对照组,差异均有统计学意义(P<0.05)。2治疗后,观察组第l秒用力呼气容积(FEV1)、第l秒用力呼气容积/肺功能包括用力肺活量(FEV1/FVC)、单位肺泡一氧化碳弥散量(DLCO/VA)均显著高于对照组,差异均有统计学意义(P<0.05)。结论:补充维生素D可提高COPD患者骨密度,降低炎症因子水平,并改善肺功能。

Effect of Vitamin D Supplement on Bone Mineral Density and Inflammatory Factors in Patients with COPD

Objective： To explore the effect of vitamin D supplement on bone mineral density and inflammatory factors in patients with COPD. Methods： 350 patients COPD were randomly divided into the observation group（n=175） and the control group（n=175）. They al received the conventional treatment, but the patients in the observed group were given the treatment of Calcitriol Soft Capsules （0.25 μg·d-1）. The difference of the bone mineral density, inflammatory cytokines and pulmonary function were compared between the two group after treatment for 3 months. Results： ① After treatment, the levels of 25 （OH） D, serum calcium, bone mineral density and T values in the observation group were significantly higher than those of the control group, while the levels of serum phosphorus, TNF- α and IL-6 in the observation group were significantly lower than those of the control group（P〈0.05）. ② After the treatment, the FEV1, FEV1/FVC and DLCO/VA in the observation group were significantly higher than those of the control group（P〈0.05）. Conclusion： Vitamin D supplement could improve bone mineral density, decrease the level of inflammatory factors, and improve lung function in patients with COPD.