非人灵长类弓形虫病研究进展

弓形虫(Toxoplasma gondii)是一种专性细胞内寄生的机会性致病原虫, 呈世界性分布, 引起严重的人兽共患弓形虫病, 目前防控该病尚无理想的药物和疫苗。非人灵长类动物由于其遗传物质、形态结构与人类具有更高的相似性而成为人类疾病研究中理想的动物模型。新大陆灵长类对弓形虫具有较强的易感性, 而旧大陆灵长类感染弓形虫与人类感染弓形虫一样多呈亚临床感染。非人灵长类弓形虫病的研究主要集中在流行病学研究、临床症状、先天性弓形虫病的防治、治疗药物的筛选和疫苗开发等方面, 本文就近年来国内外非人灵长类动物弓形虫病研究进展作一综述。

A review of toxoplasmosis in nonhuman primates

Toxoplasma gondii is an obligate intracellular protozoan parasite that causes zoonotic parasitic disease-toxo-plasmosis.This parasite can infect a wide range of mammals and birds throughout the world.There is no effective drug or vaccine for prevention of this disease to humans.Because of their phylogenetic and morphology proximity to humans,nonhuman primates have been used extensively as ideal animal models.New World monkeys are highly susceptible to toxoplasmosis,but Old World monkeys are resistant to T.gondii as humans with sub-clinical toxoplasmosis.The researches focused on the sero epidemiologic,horizontal transmission,congenital toxoplasmosis,clinical toxoplasmosis,screening therapeutic drug,vaccine and so on.This paper reviews recent advances of toxoplasmosis researches on nonhuman primates.