| 褪黑素水平对抑郁症患者下丘脑-垂体-肾上腺轴功能的影响 |
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| 引用本文： | 陈淑玲,倪明慧,徐乐平.褪黑素水平对抑郁症患者下丘脑-垂体-肾上腺轴功能的影响[J].中国健康心理学杂志,2014,0(9):1293-1296. |
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| 作者姓名： | 陈淑玲 倪明慧 徐乐平 |
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| 作者单位： | 陈淑玲(中国.江苏省金坛第二人民医院精神科 213200)；倪明慧(中国.江苏省金坛第二人民医院精神科 213200)； 徐乐平 (解放军第102医院 常州)； |
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| 摘 要： | 目的探讨抑郁症患者褪黑素(MT)水平对下丘脑-垂体-肾上腺轴(HPA)功能的影响。方法对86例抑郁症患者,检测血清MT、促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、皮质醇(COR),并分析其相互关系。结果1以MT中位数(51.3ng/L)为切点,将所有抑郁症患者分为MT高值组(51.3ng/L,n=43)与MT低值组(51.3ng/L,n=43),前者血清CRH、ACTH、COR均显著低于后者(t=3.330,3.315,2.314;P0.01,0.01,0.05);2血清MT水平与CRH、ACTH水平负相关(r=-0.414,-0.329;P0.01,0.05)。结论褪黑素对抑郁症患者的HPA轴功能可能有一定的抑制作用。
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| 关 键 词： | 抑郁症 褪黑素 下丘脑-垂体-肾上腺轴 精神病学 |
The Influences of Melatonin on Activity of Hypothalamic-pituitary-adrenal Axis in Depression |
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| Institution: | Chen Shuling,Ni Minghui ,Xu Leping.( Department of Psychiatry, The Second People＆ Hospital of Jingtan, Changzhou 213200 ,P. R. China.) |
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| Abstract: | Objective To study the effects of melatonin（MT） on activity of hypothalamic -pituitary-adrenal（HPA） axis in depression.Methods Major depression patients（n=86） were rolled for the study and assigned to be tested by MT ,corticotrophin releasing hormone（CRH）,adrenocorticotrophin hormone （ACTH）,cortisol（COR） and 17-items hamilton depression scale for analysis .Results Divided by the median of serum MT level （51.3ng/L）,the patients who had higher MT level （〉51.3ng/L） had significantly decreased level of CRH,ACTH,COR （t=3.330,3.315,2.314;P〈0.01,0.01,0.05） than those who had lower MT level（〈51.3ng/L,n=43）. The serum level of MT was markedly related with CRH （r=-0.414,P〈0.01） or ACTH（r=-0.329,P〈0.05）.Conclusion Melatonin may inhibit the activity of hypothalamic -pituitary-adrenal axis in patients with depression . |
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| Keywords: | Depression Melatonin Hypothalamic-pituitary-adrenal axis Psychiatry |
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