| 热休克蛋白27在调控细胞凋亡过程中的作用 |
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| 引用本文： | 刘金娟,崔毓桂,刘嘉茵. 热休克蛋白27在调控细胞凋亡过程中的作用[J]. 医学综述, 2009, 15(13): 1921-1923 |
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| 作者姓名： | 刘金娟 崔毓桂 刘嘉茵 |
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| 作者单位： | 1. 中国药科大学生命科学与技术学院,南京,210038;南京医科大学第一附属医院生殖医学中心,南京,210029
2. 南京医科大学第一附属医院生殖医学中心,南京,210029 |
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| 摘 要： | 热休克蛋白是一类广泛存在于生物体内、生物进化高度保守、在生理和应激条件下均能表达的蛋白质家族。HSP27是该家族中重要成员之一,它的表达与应激条件下增加细胞的存活率相关。HSP27通过与凋亡通路中的一些重要蛋白相互作用参与细胞凋亡的调控。
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| 关 键 词： | 热休克蛋白27 细胞凋亡 信号转导 应激 |
The Role of HSP27 in Regulating Apoptosis |
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| LIU Jin-juan,CUI Yu-gui,LIU Jia-yin. The Role of HSP27 in Regulating Apoptosis[J]. Medical Recapitulate, 2009, 15(13): 1921-1923 |
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| Authors: | LIU Jin-juan CUI Yu-gui LIU Jia-yin |
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| Affiliation: | LIU Jin-juan, CUI Yu-gui, LIU Jia-yin. ( 1. Department of Life Science And Technology, China Pharmaceutical University, Nanjing 210038, China; 2. Center of Clinical Reproductive Medieine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ) |
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| Abstract: | Heat shock proteins （HSPs） are ubiquitous in organisms, with high conservative in organic evolution and expression in physiological condition or stress response. HSP27 which correlated with increasing cell survival in stress response is significant one of the HSPs family. It has been shown that HSP2. 7 regulates apoptosis to prevent cell death by interacting with a large number of important proteins m apoptotic signal pathway. |
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| Keywords: | Heat shock proteins27 Apoptosis Signal transduction Stress |
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