| IL-23的研究进展 |
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| 引用本文： | 徐玢,马小彤.IL-23的研究进展[J].医学分子生物学杂志,2004,1(5):302-305. |
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| 作者姓名： | 徐玢 马小彤 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,血液学研究所,天津市,300020;中国医学科学院,中国协和医科大学,血液学研究所,天津市,300020 |
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| 摘 要： | IL 2 3是新近发现的一种细胞因子 ,主要来源于活化的单核巨噬细胞和B细胞。它具有多种生物学功能 ,能促进T细胞尤其是CD4 T细胞增殖 ,促进T细胞、抗原提呈细胞产生IFN γ与IL 12 ,对树突状细胞的共刺激功能起调节作用 ,具有抗肿瘤和抗转移活性 ,而且与自身免疫和炎症反应疾病密切相关。
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| 关 键 词： | IL-23 IL-12 细胞因子 |
| 修稿时间： | 2004年4月27日 |
Advances in the Study of IL-23 |
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| XU Bin,MA Xiaotong Chinese Academy of Medical Sciences,Peking Union Medical College.Advances in the Study of IL-23[J].Journal of Medical Molecular Biology,2004,1(5):302-305. |
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| Authors: | XU Bin MA Xiaotong Chinese Academy of Medical Sciences Peking Union Medical College |
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| Institution: | XU Bin,MA Xiaotong Chinese Academy of Medical Sciences,Peking Union Medical College,Institute of Hematology,Tianjin,300020,China |
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| Abstract: | IL-23 is a recently discovered heterodimeric cytokine. It is mainly produced by activated macrophages and B cells. IL-23 has been shown to possess multiple biological activities. For example, it can enhance T cells especially CD4 T cell proliferation and interferon-gamma, IL-12 production from T cells, myeloid antigen-presenting cells (APCs). It can also modulate the costimulatory function of dendritic cells (DC). Additionally, recent studies demonstrated that IL-23 has antitumor and antimetastatic activity, and it may also be involved in the development of autoimmune diseases and inflammatory diseases. |
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| Keywords: | IL-23 IL-12 cytokine |
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