| 心脉龙与香丹及参脉注射液对大鼠草鱼胆中毒早期肾脏损害的影响 |
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| 引用本文： | 吴建新,钮荣祥,董丛丽. 心脉龙与香丹及参脉注射液对大鼠草鱼胆中毒早期肾脏损害的影响[J]. 中西医结合学报, 2004, 2(1): 33-35 |
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| 作者姓名： | 吴建新 钮荣祥 董丛丽 |
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| 作者单位： | 云南大理学院生理学与病理生理学教研室,云南,大理,671000 |
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| 基金项目： | 云南省大理州科技局基金 |
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| 摘 要： | 目的:观察心脉龙、香丹、参脉注射液对大鼠草鱼胆中毒早期肾脏损害的影响,为中药治疗草鱼胆中毒所致的肾脏损害提供实验依据. 方法:SD大鼠1次胃饲大理地区草鱼胆汁(6 ml/kg),复制草鱼胆中毒模型,10 min后分别腹腔注射心脉龙、香丹或参脉注射液.结果:上述中药均能降低血肌酐和血尿素氮的水平,增加肌酐清除率,减少近曲小管上皮细胞坏死及囊腔内有红细胞的肾小球数目,与对照组比较,P ＜0.01. 结论:中药制剂心脉龙、香丹、参脉注射液对大鼠草鱼胆中毒所致的早期肾脏损害均有防治作用.
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| 关 键 词： | 草鱼胆 中毒 肾疾病 心脉龙注射液 香丹注射液 参脉注射液 |
| 文章编号： | 1672-1977(2004)01-0033-03 |
| 修稿时间： | 2003-06-09 |
Effects of Xinmailong,Xiangdan and Shenmai Injection on early kidney damage induced by toxin of grass carp bile |
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| WU Jian-Xin,NUI Rong-Xiang,DONG Cong-Li. Effects of Xinmailong,Xiangdan and Shenmai Injection on early kidney damage induced by toxin of grass carp bile[J]. Journal of Chinese integrative medicine, 2004, 2(1): 33-35 |
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| Authors: | WU Jian-Xin NUI Rong-Xiang DONG Cong-Li |
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| Affiliation: | Department of Physiology and Pathophysiology, Dali College, Dali, Yunnan Province 671000, China. |
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| Abstract: | Objective:To observe the effects of Xinmailong (XML), Xiangdan (XD) and Shenmai (SM) Injection on early kidney damage induced by toxin of grass carp bile (GCB) and provide experimental evidence for Chinese medicine in treating toxication of GCB. Methods:GCB (6ml/kg) was administered orally to adult SD rats to induce the model of GCB intoxication and a single intraperitoneal injection of XML, XD or SM was administered 10 min later. Results:It was found that the levels of blood creatinine and blood urea nitrogen were decreased and the creatinine clearance rate was increased by XML, XD or SM. Degenerated epithelial cells of proximal convoluted tubules and glomeruli containing red blood cells in saccular cavities were decreased as compared with the normal group (P <0.01). Conclusion:The Chinese medicine XML, XD and SM Injection have therapeutic effects on early kidney damage induced by toxin of GCB. |
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| Keywords: | grass carp bile poisoning kidney diseases Xinmailong Injection Xiangdan Injection Shenmai Injection |
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