Physicochemical properties of membranes and functional status of liver mitochondria in rats with an inherited capacity for increased radical formation |
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| Authors: | R. I. Salganik I. G. Shabalina N. G. Kolosova V. N. Solov'ev N. A. Solov'eva A. R. Kolpakov |
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| Affiliation: | (1) Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk;(2) Institute of Biochemistry; Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | Liver mitochondria of inbred W/SSM rats with inherited increased radical formation reveal the following anomalies: inhibition of oxidative phosphorylation, a lowered transmembrane potential, and alterations in protein-lipid interaction. The membrane viscosity and osmotic stability of mitochondria are unaffected. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N o 6, pp. 628–631, June, 1995 |
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| Keywords: | rats of the W/SSM strain oxygen radicals mitochondria oxidative phosphorylation membrane structure |
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