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Effects of ginsenosides on vascular reactivity in rat cerebral and renal arteries
Authors:WONG Wing-tak  LEUNG Fung-ping  YUNG Lai-hang  TIAN Xiao-yu  WONG Ricky Ngok Shun  HUANG Yu
Affiliation:WONG Wing-tak1,LEUNG Fung-ping1,YUNG Lai-hang1,TIAN Xiao-yu1,WONG Ricky Ngok Shun2,HUANG Yu1(1.Department of Physiology,Chinese University of Hong Kong,Hong Kong,China,2.Department of Biology,Hong Kong Baptist University,China)
Abstract:Objective To investigate possible mechanisms underlying the antioxidant property(1)and the in vitro vasodilator effects(2)of the two ginsenosides,Rb1 and Rg1,in isolated rat renal and cerebral arteries.Methods Arterial rings were mounted in a multi-channel myograph for recording of isometric tension.To examine the antioxidant activity,some rings were exposed to a free radical-generating reaction(hypoxanthine and xanthine oxidase)with and without pre-treatment with ginsenosides.The calcium antagonistic effec...
Keywords:ginsenosides  endothelial cells  relaxation  
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