| MDR-1基因2677位点的单核苷酸多态性与白血病病人MDR-1蛋白表达水平的相关性研究 |
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| 引用本文： | 李芸,王镇南,李淑慧,元冬娟.MDR-1基因2677位点的单核苷酸多态性与白血病病人MDR-1蛋白表达水平的相关性研究[J].海南医学,2009,20(4):14-17. |
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| 作者姓名： | 李芸 王镇南 李淑慧 元冬娟 |
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| 作者单位： | 1. 广东医学院附属医院肿瘤中心,广东,湛江,524001
2. 广东医学院生化试验室,广东,湛江,524023 |
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| 摘 要： | 目的研究急性髓性白血病（Acute myeloid leukaemia,AML）病人的多药耐药基因（Multidrugresistance）MDR-1G2677T的多态性和P-gp（Permeability-glycoprotein）蛋白表达的相关性。方法采用流式细胞仪技术测定P-gp表达水平,限制性内切酶多型性-聚合酶链反应测定MDR-1G2677T多态性,并统计其相关性。结果中国AML病人中MDR-1G2677T基因座上的多态性有自己的分布特点,MDR-12677GG倾向于表达较高的P-gp。结论黄种人AML病人中MDR-1G2677T基因座上的多态性有与白种人不同的分布特点,可能为不同种族的AML病人对相同的化疗药物有效率却不同的原因之一;MDR-12677GG预测AML病人化疗敏感程度较其它携带者低,可以作为不良预后因素之一。
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| 关 键 词： | MDR-1 多态性 P-gp AML |
Predictive value of MDR-1 polymorphism for P-gp expression in AML patients |
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| LI Yun,HUANG Zhenna,LI Shuhui,et al..Predictive value of MDR-1 polymorphism for P-gp expression in AML patients[J].Hainan Medical Journal,2009,20(4):14-17. |
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| Authors: | LI Yun HUANG Zhenna LI Shuhui |
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| Institution: | LI Yun,HUANG Zhenna,LI Shuhui,et al.Cancer center,Guangdong Medical College Affiliated hospital,Zhanjiang 524001,Guangdong,P.R.CHINA |
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| Abstract: | Objective To evaluate the correlation of MDR-1 G2677T polymorphism and P-gp expression in AML peripheral blood sample.Methods P-gp expression was measured by flow-cytometry technology,while MDR-1 G2677T polymorphism was analyzed by RFLR-PCR.The correlation was examined by Kruskal-Wallis test.Results MDR-1 G2677T polymorphism in Chinese AML patients has its unique distribution which is disparate from Caucasian.Patients carried MDR-1 2677GG tends to have high P-gp expression.Conclusion The various distributio... |
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| Keywords: | MDR-1 P-gp AML |
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