| ACE2抗心室重构作用的研究进展 |
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| 引用本文： | 张培勇,蔡辉. ACE2抗心室重构作用的研究进展[J]. 医学综述, 2013, 19(3): 420-422 |
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| 作者姓名： | 张培勇 蔡辉 |
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| 作者单位： | 南方医科大学南京临床医学院;南京军区南京总医院五十区 |
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| 摘 要： | 心室重构是心脏对损伤或室壁压力增高的适应性变化,病理性心室重构导致心功能进行性恶化,最终导致心力衰竭。肾素-血管紧张素系统(RAS)通过间接和直接作用在心室重构的发生、发展中发挥重要作用。血管紧张素转换酶2(ACE2)可水解血管紧张素Ⅱ生成血管紧张素-(1-7),负性调节RAS,延缓或逆转病理型心室重构。现对近年来ACE2抗心室重构作用的研究进展进行综述。
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| 关 键 词： | 心肌肥厚 心肌纤维化 血管紧张素转换酶2 肾素-血管紧张素系统 |
Research Progress of ACE2 against Cardiac Remodeling |
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| ZHANG Pei-yong,CAI Hui. Research Progress of ACE2 against Cardiac Remodeling[J]. Medical Recapitulate, 2013, 19(3): 420-422 |
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| Authors: | ZHANG Pei-yong CAI Hui |
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| Affiliation: | 1.Nanjing School of Clinical Medicine,Southern Medical University,Nanjing 210002,China;2.Zone Fifty,Nanjing General Hospital of Nangjing Military Command,PLA,Nanjing 210002,China) |
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| Abstract: | Remodeling of the heart which occurs in response to injury and/or an increase in wall stress plays a key role in the progressive deterioration of cardiac function that leads to heart failure.The renin-angiotensin system(RAS) is a key regulator in the progress of pathological remodeling,through indirect and direct effects on cells of heart.Angiotensin converting enzyme 2(ACE2),which can break down Ang II while generating angiotensin-(1-7),can down-regulate RAS and have an important role against cardiac remodeling.Here is to make a review focusing on advances made in understanding the effects of ACE2 against cardiac remodeling. |
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| Keywords: | Cardiac remodeling Cardiac fibrosis ACE2 RAS |
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