慢性阻塞性肺疾病急性加重期住院患者肺部真菌感染的临床特点探究

目的 探究慢性阻塞性肺疾病急性加重期（AECOPD）住院患者肺部真菌感染的临床特点.方法 对我院收治的105例AECOPD住院患者按照是否出现肺部真菌感染进行分组分析.结果 共检出白色念珠球菌24例（55.8%）,光滑念珠菌12例（27.9%）,克柔念珠菌5例（11.6%）,热带念珠菌2例（4.7%）;多因素Logistic回归分析发现,年龄较高、长期ICU住院、长期使用抗生素、长期使用激素及白蛋白水平低是影响COPD急性加重期住院患者肺部真菌感染的独立危险因素（P＜0.05）;A组显效13例,有效21例,总有效率79.1%,B组显效48例,有效9例,总有效率91.9%,A组治疗效果明显低于B组（P＜0.05）.结论 COPD住院患者出现肺部真菌感染会严重影响其预后,应重视支持治疗,预防和控制感染的发生.

Study on clinical features of inpatients with AECOPD complicated with fungal infection

Objective To study the clinical features of AECOPD inpatients complicated with pulmonary fungal infection. Meth- ods 105 AECOPD patients in our hospital from May, 2008 to March, 2010 were selected to analyze whether they were complicated with pulmonary fungai infection or not. Results The infection symptoms had no obvious specificity. Fungal infection mainly were Candida ball aureus, which showed low resistance to amphotericin B. The risk factors included long-term duration of hospital stay, and use of antibiotics and hormones. The patients complicated with pulmonary infection had poor prognosis. Conclusion Pulmanary infection can seriously af- fect the prognosis of patents with AECOPD, which should be paid more attention to prevent and control the infection.