胸腺五肽对初治肺结核患者免疫功能和痰菌阴转率的影响

目的 观察应用胸腺五肽治疗初治肺结核患者对其免疫功能和痰菌阴转率的影响.方法 选取我院收治的90例初治痰涂片阳性的肺结核患者作为研究对象,按照治疗方法不同随机分为治疗组30例和对照组60例,两组患者均给予常规2HRZE/6HR化疗方案治疗,治疗组加用胸腺五肽1 ml隔日肌内注射,连续治疗8周后比较两组患者的免疫功能指标及痰菌阴转率.结果 治疗组患者治疗1、2个月时痰菌阴转率均较对照组显著增高（P〈0.01）,治疗后T细胞亚群水平较治疗前及对照组有明显差异（P〈0.05）,具有统计学意义.结论 胸腺五肽辅助治疗初治肺结核患者可改善其免疫状态、提高痰菌阴转率.

Effect of thymopentin on immunologic function and sputum negative conversion rate of patients with pulmonary tuberculosis

Objective To observe the effect of thymopentin in the treatment of pulmonary tuberculosis patients on immunologic function and sputum negative conversion rates of sputum tuberculosis. Methods 90 patients with pulmonary tuberculosis whose sputum smear was positive after initial treatment were randomly divided into the treatment group with 30 cases and the control group with 60 cases. All patients were treated with conventional chemotherapy of 2HRZE/6I-IR, and the treatment group was treated with lml of thymopentin every other day through intramuscular injection. 8 weeks after the treatment, the indexes of immune function and the rate of sputum nega- tive conversion rate were compared between the two groups. Results 1 - 2 mouths after the treatment, the rate of sputum negative conver- sion was significantly higher in the treatment group than in the control group （P 〈 0. 01 ）. There existed significant difference on the level of T cell subsets between the two groups （P 〈 0. 05 ）. Conclusion Thymopentin can improve the immune status and the rate of sputum negative conversion in the adjuvant treatment of pulmonary tuberculosis patients.