雷贝拉唑钠肠溶片致肝损伤

1例45岁男性患者因反酸给予雷贝拉唑钠肠溶片10 mg,1次/d。3周后因症状加重自行加倍服药。3 d后出现全身乏力、食欲减退、小便深黄。停用雷贝拉唑钠肠溶片。实验室检查：丙氨酸转氨酶401 U/L,天冬氨酸转氨酶314 U/L,碱性磷酸酶143 U/L,γ-L-谷氨酰转移酶359 U/L,总胆红素22.7μmol/L。给予保肝治疗。1周后复查,丙氨酸转氨酶40 U/L,天冬氨酸转氨酶15 U/L。

Liver injury induced by rabeprazole sodium enteric-coated tablets

A 45-year-old man received rabeprazole sodium enteric-coated tablets 10 mg once daily for acid regurgitation.Three week later,the symptom worsened,so he self-medicated double dosage.He developed generalized weakness,inappetence,dark yellow urine after 3 days.Rabeprazole sodium entericcoated tablets was stopped.Laboratory tests showed the following values;alanine aminotransferase 401 U/mL, aspartate aminotransferase 314 U/mL,alkaline phosphatase 143 U/mL,γ-glutamyl transferase 359 U/mL, total bilirubin 22.7 μmol/L.He was given liver protective drugs.One week later,the levels of alanine aminotransferase and aspartate aminotransferase were 40 U/L and 15 U/L,respectively.