川芎嗪对先天性心脏病肺动脉高压体外循环下血栓素A2及前列环素的影响

目的 :探讨川芎嗪对先天性心脏病肺动脉高压患者体外循环下血栓素A2(TXA2 ) /前列环素 (PGI2 )平衡的保护作用。方法 :将 3 0例非紫绀型先天性心脏病肺动脉高压患者随机分为对照组 (1 5例 )和用药组 (1 5例 )。川芎嗪分别于麻醉诱导后静脉滴注 3mg/kg及转流后加入氧合器中 1mg/kg ,分别于麻醉诱导后、转流 1 5min、升主动脉开放 5min、停机后2 0min、6h及 2 4h采血并测定TXA2 、PGI2 。结果 :用药组与对照组比较 ,除术前、停机后 2 4h外 ,其余各时点均有显著性差异 (P <0 0 1 )。结论 :川芎嗪能纠正先天性心脏病肺动脉高压患者体外循环下TXA2 、PGI2 的失衡。

Effects in Tetramethylpyrazine on TXA_2 and PGI_2 by Cardio Pulmonary Bypass in Congenital Heart Diseases with Pulmonary Hypertension Patients

Objective: To study protective effects of tetramethylpyrazine (TMP) on the imbalance of TXA 2/PGI 2 during cardiopulmomary bypass (CPB) in congenital heart disease (CHD) with pulmonary hypertension (PH) patients. Methods: Thirty patients suffered from non cyanotic CHD PH were randomly divided into control group (n=15) and treatment group (n=15). 3 mg/kg of TMP was dripped intravenously after anesthesia and 1 mg/kg of TMP was infused into oxygenator after CPB individually. Blood samples were collected and TXA 2 as well as PGI 2 were measured after anesthesia induction, 15 min during CPB, 5 min after release of the aortic cross clamp,and 20 min, 6 hrs and 24 hrs after CPB. Results: There was significant difference between treatment group and control group except before operation and 24 hrs after CPB. Conclusions: The imbalance of TXA 2 and PGI 2 in patients with CHD PH during CPB could correct by TMP.