Role of hypofractionated radiotherapy in breast locoregional radiation |
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| Affiliation: | 1. Department of Radiation Medicine, The Ottawa Hospital Cancer Centre, 501 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada;2. Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Island Centre, Victoria, British Columbia, Canada;1. Joint Department of Physics at The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK;2. Oncology Centre, Colchester Hospital University NHS Trust, Colchester, UK;3. Faculty of Health Sciences, University of Southampton, Southampton, UK;4. ICR-CTSU, Institute of Cancer Research, Sutton, UK;5. Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK;1. Department of Forest Resources and Environmental Conservation, Virginia Tech, Blacksburg, VA 24061, USA;2. Center for Sustainable and Renewable Resources, Institute of Advanced Learning and Research, Danville, VA 24540, USA;1. Tianjin Key Laboratory of Marine Resources and Chemistry, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300457, PR China;2. National Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, PR China;1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA;2. Department of Radiotherapy, Gustave Roussy Cancer Campus, Villejuif, France;3. Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA |
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| Abstract: | Long-term results of randomised trials have confirmed the safety and efficacy of hypofractionated radiotherapy using approximately 2.6 Gy per fraction to lower total doses of 40–42.6 Gy delivered over 3 weeks, for postoperative treatment of early breast cancer. In these trials, hypofractionated radiotherapy was predominantly used for breast only treatment, while there are fewer trials that specifically examined hypofractionated radiotherapy to the breast plus regional nodes. Hypofractionated locoregional radiation is considered a standard of care in the United Kingdom and in some parts of Canada. We aim to review the radiobiology and normal tissue effects of hypofractionated locoregional radiation and to summarize available published clinical experiences using this treatment strategy as adjuvant therapy after breast conserving surgery or mastectomy for women with early breast cancer. |
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| Keywords: | Breast cancer Regional nodal radiation Hypofractionated Cancer du sein Irradiation ganglionnaires Hypofractionnement |
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