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Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis
Institution:1. Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK;2. Biodiversity Institute and Departments of Anthropology and Geology, University of Kansas, Lawrence, KS 66045, USA;3. Kuvin Center for the Study of Infectious and Tropical Diseases and Ancient DNA, Hadassah Medical School, Hebrew University, Jerusalem, Israel;4. Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;5. Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel;6. Centres for Clinical Microbiology and the History of Medicine, University College London, UK;1. Centre d''Etudes Paléopathologiques du Nord, 36 rue Jules Ferry, 59127 Walincourt-Selvigny, France;2. Lille University, Forensic Taphonomy Unit-Anthropology, Lille Forensic Institute, 59000, France;3. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA;4. University of Bordeaux, CNRS-PACEA-UMR 5199, B8, Avenue des Facultés, 33405 Talence, France;1. De la Préhistoire à l’Actuel: Culture, Environnement, Anthropologie (PACEA – UMR 5199, CNRS – Université de Bordeaux – Ministère de la Culture et de la Communication), Allée Geoffroy Saint-Hilaire, 33615 Pessac Cedex, France;2. Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany;3. Laboratoire Bordelais de Recherche en Informatique (UMR 5800 LaBRI), Université de Bordeaux, 351 Cours de la Libération, 33405 Talence, France;4. National Museum of Natural History, Department of Anthropology, Budapest, Hungary;5. Laboratoire d''Anthropologie biologique Paul Broca, EPHE (Ecole Pratique des Hautes Etudes), Paris, France;6. Service d''Imagerie médicale, Centre Hospitalo-Universitaire de Bordeaux, France;7. Service d''Imagerie médicale, Centre Hospitalo-Universitaire de Marseille, France;8. Department of Diagnostic Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary;9. Department of Biological Anthropology, University of Szeged, Hungary;10. Department of Anthropology, University of Western Ontario, Canada;1. Laboratory of Molecular Biology Applied to Mycobacteria, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil;2. Laboratory of Biology of Recognition, Universidade Estadual do Norte Fluminense, Rio de Janeiro, Brazil;3. Laboratory of Bacterial Pathogenesis and Molecular Biology, Unicamp, São Paulo, Brazil;4. Instituto Adolfo Lutz, São Paulo, Brazil;5. Laboratorio de Micobacteriologia Molecular do Centro de Pesquisas em Doenças Infecciosas e Parasitarias, University Hospital Clementino Fraga Filho, UFRJ, Rio de Janeiro, Brazil;6. Laboratory of Molecular Microbiology, St. Petersburg Pasteur Institute, St. Petersburg, Russia;7. Laboratory of Microbiology, Research Institute of Phthisiopulmonology, St. Petersburg, Russia;1. Department of Anthropology, Hungarian Natural History Museum, Budapest, Hungary;2. Department of Biological Anthropology, University of Szeged, Szeged, Hungary;3. Semmelweis University, Department of Diagnostic Radiology and Oncotherapy, Budapest, Hungary;4. Department of Anatomy, University Medical School Göttingen, Göttingen, Germany;5. Centre for Clinical Microbiology, Division of Infection & Immunity, University College London, London, UK;6. Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;7. Centre for the History of Medicine, Division of Biosciences, University College London, UK;1. Department of Biological Anthropology, University of Szeged, Szeged, Hungary;2. Department of Genetics, University of Szeged, Szeged, Hungary;3. Institute for Mummies and the Iceman, EURAC Research, Bolzano, Italy;4. Institut de Biologie Intégrative de la Cellule I2BC CEA-CNRS-Université Paris-Saclay, UMR9198, Bât. 400 F-91405 ORSAY-Cedex, France;5. Municipal Museum of Subotica, Subotica, Serbia;6. Katona József Museum, Kecskemét, Hungary;7. Unité de Recherche MIVEGEC, UR 224/IRD, UMR 5290/CNRS, UM1, Université Montpellier 2, Montpellier, France;8. Laboratoire d''Anthropologie Biologique Paul Broca, Ecole Pratique des Hautes Etudes, UMR 5199 PACEA, Université de Bordeaux, Pessac, France;9. Department of Anthropology, University of Western Ontario, Canada
Abstract:
Keywords:Ancient tuberculosis  Lipids  Biomarkers
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