Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg,Germany |
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| Affiliation: | 1. Cardiology Department, Universitair Ziekenhuis Brussel, VUB, Belgium;2. Research Center in Epidemiology, Biostatistics and Clinical Research, School of Public Health, Université libre de Bruxelles (ULB), Belgium;3. Cardiology Department, Erasme Hospital, ULB, Belgium;4. Laboratory of Environmental Research, Brussels Environment, Brussels, Belgium;5. Division of Cardiology, Cliniques Universitaires Saint Luc Hospital and Pole de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium;6. Cardiology Department, Ghent University Hospital, Gent, Belgium;7. Cardiology Department, Mont Godine Hospital, UCL, Belgium;8. Cardiology Department, Universitair Ziekenhuis Leuven, KUL, Belgium;9. Cardiology Department, Universitair Ziekenhuis Antwerpen, UA, Belgium;1. Department of Public Health, National Taiwan University, Taipei, Taiwan;2. Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, Taiwan;3. Institute of Environmental Health, National Taiwan University, Taipei, Taiwan;4. The Experimental Forest, National Taiwan University, Nantou, Taiwan;5. The School of Forestry and Resource Conservation, National Taiwan University, Taipei, Taiwan;6. Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Taiwan;7. Institute of Statistical Science, Academia Sinica, Taipei, Taiwan;8. Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan;9. Institute of Health Policy and Management, National Taiwan University, Taipei, Taiwan;10. School of Public Health, Taipei Medical University, Taipei, Taiwan;11. Research Center for Environmental Changes, Academia Sinica, Taipei, Taiwan;12. Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan |
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| Abstract: | BackgroundShort-term exposure to increased particulate matter (PM) concentration has been reported to trigger myocardial infarction (MI). However, the association with ultrafine particles remains unclear.ObjectivesWe aimed to assess the effects of short-term air pollution and especially ultrafine particles on registry-based MI events and coronary deaths in the area of Augsburg, Germany.MethodsBetween 1995 and 2009, the MONICA/KORA myocardial infarction registry recorded 15,417 cases of MI and coronary deaths. Concentrations of PM < 10 μm (PM10), PM < 2.5 μm (PM2.5), particle number concentration (PNC) as indicator for ultrafine particles, and meteorological parameters were measured in the study region. Quasi-Poisson regression adjusting for time trend, temperature, season, and weekday was used to estimate immediate, delayed and cumulative effects of air pollutants on the occurrence of MI. The daily numbers of total MI, nonfatal and fatal events as well as incident and recurrent events were analysed.ResultsWe observed a 1.3% risk increase (95%-confidence interval: [−0.9%; 3.6%]) for all events and a 4.4% [−0.4%; 9.4%] risk increase for recurrent events per 24.3 μg/m3 increase in same day PM10 concentrations. Nonfatal events indicated a risk increase of 3.1% [−0.1%; 6.5%] with previous day PM10. No association was seen for PM2.5 which was only available from 1999 on. PNC showed a risk increase of 6.0% [0.6%; 11.7%] for recurrent events per 5529 particles/cm3 increase in 5-day average PNC.ConclusionsOur results suggested an association between short-term PM10 concentration and numbers of MI, especially for nonfatal and recurrent events. For ultrafine particles, risk increases were notably high for recurrent events. Thus, persons who already suffered a MI seemed to be more susceptible to air pollution. |
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| Keywords: | Air pollution Ultrafine particles Particulate matter Myocardial infarction Epidemiology BMI" },{" #name" :" keyword" ," $" :{" id" :" kw0035" }," $$" :[{" #name" :" text" ," _" :" body mass index CPC" },{" #name" :" keyword" ," $" :{" id" :" kw0045" }," $$" :[{" #name" :" text" ," _" :" condensation particle counter GCV" },{" #name" :" keyword" ," $" :{" id" :" kw0055" }," $$" :[{" #name" :" text" ," _" :" generalized cross-validation criteria IQR" },{" #name" :" keyword" ," $" :{" id" :" kw0065" }," $$" :[{" #name" :" text" ," _" :" interquartile range KORA" },{" #name" :" keyword" ," $" :{" id" :" kw0075" }," $$" :[{" #name" :" text" ," _" :" Cooperative Health Research in the region of Augsburg MI" },{" #name" :" keyword" ," $" :{" id" :" kw0085" }," $$" :[{" #name" :" text" ," _" :" myocardial infarction MONICA" },{" #name" :" keyword" ," $" :{" id" :" kw0095" }," $$" :[{" #name" :" text" ," _" :" monitoring of trends and determinants in cardiovascular disease RR" },{" #name" :" keyword" ," $" :{" id" :" kw0105" }," $$" :[{" #name" :" text" ," _" :" relative risk PM" },{" #name" :" keyword" ," $" :{" id" :" kw0115" }," $$" :[{" #name" :" text" ," _" :" particulate matter PNC" },{" #name" :" keyword" ," $" :{" id" :" kw0125" }," $$" :[{" #name" :" text" ," _" :" particle number concentration STEMI" },{" #name" :" keyword" ," $" :{" id" :" kw0135" }," $$" :[{" #name" :" text" ," _" :" ST segment elevation MI |
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