Translational Bioinformatics and Clinical Research (Biomedical) Informatics |
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| Institution: | 1. Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;2. Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, NY 10065, USA;1. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China;2. Heping District''s Center for Disease Control and Prevention, Tianjin 300020, Tianjin, China;3. Department of Clinical Nutrition, Hangzhou Sanatorium of People''s Liberation, Hangzhou 310013, Zhejiang, China;4. National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China;1. Cardiology Division, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA;2. Division of Cardiology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;3. Centers for Prevention and Wellness, Baptist Health South Florida, Miami, FL, USA;4. Office of Biostatistics Research, National Heart Lung and Blood Institute, Bethesda, MD, USA;5. Department of Radiology, Tufts Medical Center, Boston, MA, USA;6. Division of Radiology, Northwestern University, Chicago, IL, USA;7. Department of Medicine, University of California, Los Angeles, CA, USA;8. Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD, USA;9. Department of Radiology, Johns Hopkins University, Baltimore, MD, USA;1. Department of Surgery and Cancer Imperial College London, London, United Kingdom;2. Department of Interventional Radiology Imperial College Healthcare NHS Trust St Mary’s Hospital, 3rd floor QEQM building, Praed Street, London W21NY, United Kingdom |
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| Abstract: | Translational bioinformatics and clinical research (biomedical) informatics are the primary domains related to informatics activities that support translational research. Translational bioinformatics focuses on computational techniques in genetics, molecular biology, and systems biology. Clinical research (biomedical) informatics involves the use of informatics in discovery and management of new knowledge relating to health and disease. This article details 3 projects that are hybrid applications of translational bioinformatics and clinical research (biomedical) informatics: The Cancer Genome Atlas, the cBioPortal for Cancer Genomics, and the Memorial Sloan Kettering Cancer Center clinical variants and results database, all designed to facilitate insights into cancer biology and clinical/therapeutic correlations. |
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| Keywords: | Translational informatics Bioinformatics Clinical research informatics Biomedical informatics The Cancer Genome Atlas TCGA cBioPortal Cancer genomics |
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