Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study |
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| Affiliation: | 1. Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;2. Department of Exposure and Risk Assessment, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway;3. Institute for Environmental Studies, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands;4. Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway;1. Division of Environmental Hazards and Health Effects, National Center for Environmental Health (NCEH), Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Atlanta, GA, USA;2. Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA;3. Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA, USA;4. School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, UK;1. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan;2. Department of Occupational Therapy, School of Sciences, Sapporo Medical University, Sapporo, Japan;3. Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan;4. Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan;1. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA;2. Department of Occupational Medicine and Public Health, Faroese Hospital System, Torshavn, Faroe Islands;3. Institute of Public Health, University of Southern Denmark, Odense, Denmark |
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| Abstract: | BackgroundPerfluoroalkyl substances (PFASs) are a group of fluorinated organic substances that are widely used in consumer products and are often detectable in human tissues. Human studies on prenatal exposure to PFASs and neurodevelopment in children are few and inconsistent.MethodsIn the Taiwan Maternal and Infant Cohort Study, we collected serum samples from pregnant women during the third trimester and measured concentrations of 9 PFASs using a high performance liquid chromatography system. A subsample of their children was assessed with full scale intelligence quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ) at both age 5 (n = 120) and 8 years (n = 120). We used multivariate linear regression models to examine prenatal PFAS exposure in relation to IQ scores at each age period.ResultsPrenatal perfluoroundecanoic acid (PFUnDA) concentrations were inversely associated with children's PIQ scores at age 5 years, with an adjusted coefficient (β) of −1.6 (95% confidence interval [CI]: (−3.0, −0.2). When children reached 8 years, most of the prenatal PFASs showed inverse association with children's FSIQ, VIQ and PIQ scores. Among them, prenatal perfluorononanoic acid (PFNA) reached significance. Children with higher prenatal PFNA levels had lower VIQ with an adjusted β of −2.1 (95% CI: −3.9, −0.2).ConclusionsWe found two prenatal PFAS exposure, both long-chain PFASs, in association with decreased IQ test scores in children. Our findings suggest more studies on long-chain PFASs and children's neurodevelopment. |
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| Keywords: | Perfluoroalkyl substances Prenatal exposure IQ Children ADHD" },{" #name" :" keyword" ," $" :{" id" :" kw0030" }," $$" :[{" #name" :" text" ," _" :" attention deficit hyperactivity disorder β" },{" #name" :" keyword" ," $" :{" id" :" kw0040" }," $$" :[{" #name" :" text" ," _" :" coefficient CI" },{" #name" :" keyword" ," $" :{" id" :" kw0050" }," $$" :[{" #name" :" text" ," _" :" confidence interval CV" },{" #name" :" keyword" ," $" :{" id" :" kw0060" }," $$" :[{" #name" :" text" ," _" :" coefficients of variation FSIQ" },{" #name" :" keyword" ," $" :{" id" :" kw0070" }," $$" :[{" #name" :" text" ," _" :" full scale IQ GM" },{" #name" :" keyword" ," $" :{" id" :" kw0080" }," $$" :[{" #name" :" text" ," _" :" geometric mean HOME" },{" #name" :" keyword" ," $" :{" id" :" kw0090" }," $$" :[{" #name" :" text" ," _" :" home observation for measurement of the environment inventory LOQ" },{" #name" :" keyword" ," $" :{" id" :" kw0100" }," $$" :[{" #name" :" text" ," _" :" limit of quantitation IQR" },{" #name" :" keyword" ," $" :{" id" :" kw0110" }," $$" :[{" #name" :" text" ," _" :" interquartile range PCBp" },{" #name" :" keyword" ," $" :{" id" :" kw0120" }," $$" :[{" #name" :" text" ," _" :" olychlorinated biphenyl PFASs" },{" #name" :" keyword" ," $" :{" id" :" kw0130" }," $$" :[{" #name" :" text" ," _" :" perfluroalkyl substances PFDeA" },{" #name" :" keyword" ," $" :{" id" :" kw0140" }," $$" :[{" #name" :" text" ," _" :" perfluorodecanoic acid PFHpA" },{" #name" :" keyword" ," $" :{" id" :" kw0150" }," $$" :[{" #name" :" text" ," _" :" perfluoroheptanoic acid PFHxA" },{" #name" :" keyword" ," $" :{" id" :" kw0160" }," $$" :[{" #name" :" text" ," _" :" perfluorohexanoic acid PFHxS" },{" #name" :" keyword" ," $" :{" id" :" kw0170" }," $$" :[{" #name" :" text" ," _" :" perfluorohexanesulfonic acid PFOS" },{" #name" :" keyword" ," $" :{" id" :" kw0180" }," $$" :[{" #name" :" text" ," _" :" perfluorooctane sulfonate PFOA" },{" #name" :" keyword" ," $" :{" id" :" kw0190" }," $$" :[{" #name" :" text" ," _" :" perfluorooctanoic acid PFNA" },{" #name" :" keyword" ," $" :{" id" :" kw0200" }," $$" :[{" #name" :" text" ," _" :" perfluorononanoic acid PFUnDA" },{" #name" :" keyword" ," $" :{" id" :" kw0210" }," $$" :[{" #name" :" text" ," _" :" perfluoroundecanoic acid PFDoDA" },{" #name" :" keyword" ," $" :{" id" :" kw0220" }," $$" :[{" #name" :" text" ," _" :" perfluorododecanoic acid PIQ" },{" #name" :" keyword" ," $" :{" id" :" kw0230" }," $$" :[{" #name" :" text" ," _" :" performance IQ SD" },{" #name" :" keyword" ," $" :{" id" :" kw0240" }," $$" :[{" #name" :" text" ," _" :" standard deviation TMICS" },{" #name" :" keyword" ," $" :{" id" :" kw0250" }," $$" :[{" #name" :" text" ," _" :" Taiwan maternal and infant cohort study VIQ" },{" #name" :" keyword" ," $" :{" id" :" kw0260" }," $$" :[{" #name" :" text" ," _" :" verbal IQ WPPSI-R" },{" #name" :" keyword" ," $" :{" id" :" kw0270" }," $$" :[{" #name" :" text" ," _" :" Wechsler preschool and primary scale of intelligence-revised WISC-III" },{" #name" :" keyword" ," $" :{" id" :" kw0280" }," $$" :[{" #name" :" text" ," _" :" Chinese version of Wechsler's intelligence scale for children-III |
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