Low Testosterone Has a Similar Prevalence among Men with Sexual Dysfunction Due to Either Peyronie's Disease or Erectile Dysfunction and Does Not Correlate with Peyronie's Disease Severity |
| |
| Institution: | 1. Department of Sexual Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, China;2. Clinic for Psychiatry and Psychotherapy, Faculty of Medicine, University of Magdeburg, Magdeburg, Germany;3. Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany;4. Division of Forensic Psychiatry, Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL-University Hospital Bochum, Bochum, Germany;2. Department of Urology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea;3. Department of Urology, Seoul National University Boramae Hospital, Seoul, Korea;2. Serviço de Urologia, Hospital Santo Antonio, Porto, Portugal;3. Unidad de Investigación Traslacional en Cardiología, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, Spain;4. Serviço de Urologia, Hospital Amadora-Sintra, Lisboa, Portugal;2. New England Research Institutes, Inc., Watertown, MA, USA;3. SUNY—Downstate Medical Center, Brooklyn, NY, USA;4. NY Weill Cornell Medical Center, New York, NY, USA;2. Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands;3. Department of Radiotherapy, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands |
| |
| Abstract: | IntroductionLow testosterone (T) has been suggested as a risk factor for Peyronie's disease (PD) that may correlate with disease severity. Low T is common in men with sexual dysfunction but its role in the pathogenesis of PD remains unclear.AimThe aim of this study was to compare the prevalence of low T (<300 ng/dL) in patients presenting with PD or erectile dysfunction (ED), as well as disease severity between men with PD and either low T or normal T (≥300 ng/dL).MethodsRetrospective review of 300 men with either PD or ED was conducted. Men were excluded for combined PD and ED, psychogenic ED, or prior T use. For men with PD, plaque size, degree of curvature, and surgical correction rate were compared.Main Outcome MeasuresThe main outcome measures were (i) mean T levels in men with PD or ED and (ii) plaque size, degree of curvature, and surgical correction rates among men with PD and either low T or normal T.ResultsEighty‐seven men with PD and 98 men with ED were identified. Men with PD had mean total T and free T of 328 ng/dL and 11.5 ng/dL, while men with ED had mean levels of 332 ng/dL and 12.1 ng/dL, respectively (P > 0.05). Of PD men, 52.9% had low T, compared with 45.9% of men with ED (P = 0.35). T levels did not correlate with plaque size or degree of curvature in the PD group (P > 0.05).ConclusionsMen with sexual dysfunction characterized by either PD or ED had similarly low T levels, and low T did not correlate with PD severity or surgical correction rate. The comparable prevalence of low T in men with PD or ED suggests the high rate of low T in PD men may be related to a common process among men with abnormal erectile physiology and not specifically causative in plaque formation. Kirby EW, Verges D, Matthews J, Carson CC, and Coward RM. Low testosterone has a similar prevalence among men with sexual dysfunction due to either Peyronie's disease or erectile dysfunction and does not correlate with Peyronie's disease severity. J Sex Med 2015;12:690–696. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
