Molecular Updates in Prostate Cancer |
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| Affiliation: | 1. Livestock Genetics, Department Biosystems, Faculty of Bioscience Engineering, KU Leuven, Kasteelpark Arenberg 30, B-3001 Heverlee, Belgium;2. Laboratory of Chemical Analysis, Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium;3. Animal Sciences Unit, Institute for Agricultural and Fisheries Research (ILVO), Scheldeweg 68, B-9090 Melle, Belgium |
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| Abstract: | A wide array of molecular markers and genomic signatures, reviewed in this article, may soon be used as adjuncts to currently established screening strategies, prognostic parameters, and early detection markers. Markers of genetic susceptibility to PCA, recurrent epigenetic and genetic alterations, including ETS gene fusions, PTEN alterations, and urine-based early detection marker PCA3, are discussed. Impact of recent genome-wide assessment on our understanding of key pathways of PCA development and progression and their potential clinical implications are highlighted. |
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| Keywords: | Prostate cancer Carcinogenesis Genomic classification |
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