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Mechanisms of ventilator-induced lung injury in healthy lungs
Institution:1. Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, Bloco G-014, Ilha do Fundão, 21941-902, Rio de Janeiro, Brazil;2. Department of Surgical and Morphological Sciences, University of Insubria, Via J.H. Dunant 5, Varese, Italy;1. Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, the Netherlands;2. Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands;3. Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands;4. Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;5. Department of Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy;6. Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK;7. Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea;8. Pancreatic Surgery Unit, Division of Surgery, Karolinska Institute at Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden;9. Department of Surgery, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, the Netherlands;10. Department of Surgery, Royal North Shore Hospital, St Leonards, University of Sydney, Sydney, NSW, Australia;11. Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research and University of Sydney, Sydney, NSW, Australia;12. Department of Surgery, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany;13. Division of Surgical Oncology, Department of Surgery, University of Colorado at Denver-Anschutz Medical Campus, Aurora, CO, USA;14. Section of Hepato-Pancreato-Biliary & Endocrine Surgery, Virginia Mason Medical Center, Seattle, WA, USA;1. Department of Anaesthesiology, Hospital del Mar, Universitat Autònoma de Barcelona, Institut Hospital del Mar d''Investigacions Mèdiques (IMIM), Passeig Maritim 25, 08003 Barcelona, Spain;2. Department of Anaesthesiology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Carretera del Canyet s/n, Badalona, 08916 Barcelona, Spain;1. Division of Pulmonary and Critical Care Medicine, University of California, San Diego, 200 West Arbor Drive, #8409, San Diego, CA 92103, USA;2. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, Cox 201, Boston, MA 02114, USA;1. Institut Universitaire de Cardiologie et Pneumologie de Québec, Faculté de Médecine, Université Laval, Ville de Québec, Canada;2. CHU de Bordeaux, Service d''Anesthésie-Réanimation II, Univ. Bordeaux, Adaptation Cardiovasculaire à l''ischémie, U1034 et INSERM, Adaptation Cardiovasculaire à l''ischémie, U1034, F-33600 Pessac, France;1. Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden;2. Department of Anaesthesia and Intensive Care, Karolinska Hospital, Huddinge, Sweden;3. Department of Anaesthesia and Intensive Care, University Hospital, Uppsala, Sweden;4. Department of Intensive Care Medicine, University Hospital (Inselspital), University of Bern, Bern, Switzerland;5. Department of Anaesthesia and Intensive Care, Västerås Hospital, Västerås, Sweden;6. Centre for Clinical Research, Uppsala University, Hospital of Västmanland, Västerås, Sweden
Abstract:
Keywords:cytokines  elastance  positive end-expiratory pressure  recruitment maneuvers  transpulmonary pressure
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