Adult Renal Cell Carcinoma: A Review of Established Entities from Morphology to Molecular Genetics |
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Affiliation: | 1. Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;2. Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan;3. Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan |
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Abstract: | According to the current World Health Organization (WHO), renal cell carcinomas (RCCs) that primarily affect adults are classified into 8 major subtypes. Additional emerging entities in renal neoplasia have also been recently recognized and these are discussed in further detail by Mehra et al (Emerging Entities in Renal Neoplasia, Surgical Pathology Clinics, 2015, Volume 8, Issue 4). In most cases, the diagnosis of a RCC subtype can be based on morphologic criteria, but in some circumstances the use of ancillary studies can aid in the diagnosis. This review discusses the morphologic, genetic, and molecular findings in RCCs previously recognized by the WHO, and provides clues to distinction from each other and some of the newer subtypes of RCC. As prognosis and therapeutic options vary for the different subtypes of RCC, accurate pathologic distinction is critical for patient care. |
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Keywords: | Renal cell carcinoma Clear cell Papillary Chromophobe Mucinous tubular and spindle cell carcinoma Translocation Xp11.2 Collecting duct |
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