Improved Stability of Proline-Derived Direct Thrombin
Inhibitors through Hydroxyl to Heterocycle Replacement |
| |
| Authors: | Harry R. Chobanian,Barbara Pio,Yan Guo,Hong Shen,Mark A. Huffman,Maria Madeira,Gino Salituro,Jenna
L. Terebetski,James Ormes,Nina Jochnowitz,Lizbeth Hoos,Yuchen Zhou,Dale Lewis,Brian Hawes,Lyndon Mitnaul,Kim O’Neill,Kenneth Ellsworth,Liangsu Wang,Tesfaye Biftu,Joseph L. Duffy |
| |
| Affiliation: | Departments of †Medicinal Chemistry, ‡Process Chemistry, §Drug Metabolism and Pharmacokinetics, ∥Preclinical Development, ⊥Pharmacology, and #Thrombosis, Merck Research Laboratories, Kenilworth, New Jersey 07033, United States |
| |
| Abstract: | | |
| Keywords: | Thrombin proline dabigatran thrombosis warfarin serine protease |
|
|
