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Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement |
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| Authors: | Harry R Chobanian Barbara Pio Yan Guo Hong Shen Mark A Huffman Maria Madeira Gino Salituro Jenna&#;L Terebetski James Ormes Nina Jochnowitz Lizbeth Hoos Yuchen Zhou Dale Lewis Brian Hawes Lyndon Mitnaul Kim O’Neill Kenneth Ellsworth Liangsu Wang Tesfaye Biftu Joseph L Duffy | |
| Institution: | Departments of †Medicinal Chemistry, ‡Process Chemistry, §Drug Metabolism and Pharmacokinetics, ∥Preclinical Development, ⊥Pharmacology, and #Thrombosis, Merck Research Laboratories, Kenilworth, New Jersey 07033, United States | |
| Abstract: | ||
| Keywords: | Thrombin proline dabigatran thrombosis warfarin serine protease | |