Influence of Androgen Receptor CAG Polymorphism on Sexual Function Recovery after Testosterone Therapy in Late‐Onset Hypogonadism |
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| Institution: | 2. Endocrinology Unit, Maggiore-Bellaria Hospital, Bologna, Italy;3. Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy;2. CUNY School of Public Health at Hunter College, New York, NY, USA;3. Department of Health and Nutrition Sciences, Brooklyn College of the City University of New York (CUNY), Brooklyn, NY, USA;4. Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;5. Department of Psychology, Hunter College of the City University of New York (CUNY), New York, NY, USA;2. Division of Endocrinology, Charles Drew University of Medicine and Science, Los Angeles, CA, USA;3. Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA;2. Department of Geriatrics, Changhai Hospital, Second Military Medical University, Shanghai, China;3. Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai, China;2. Faculty of Medicine, Division of Cardiology, Foundation for Medical Researches, Geneva University Hospitals, Geneva, Switzerland;3. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy;4. Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA;5. Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil;2. Inflammation Research Center, VIB, Ghent, Belgium;3. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium |
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| Abstract: | IntroductionAndrogen receptor (AR) CAG polymorphism has been found to influence sexual function. However, no study has evaluated its potential to condition sexual function recovery after testosterone replacement therapy (TRT) in a large cohort of hypogonadic subjects.AimTo evaluate the role of this polymorphism in sexual function improvement after TRT in late‐onset hypogonadism (LOH).MethodsSeventy‐three men affected by LOH were retrospectively considered. Evaluations were performed before TRT started (time 0) and before the sixth undecanoate testosterone injection.Main Outcome MeasuresInternational Index of Erectile Function (IIEF) questionnaire (erectile function EF], orgasmic function OF], sexual desire SD], intercourse satisfaction IS], overall satisfaction OS], and total IIEF‐15 score); total and free testosterone and estradiol; AR gene CAG repeat number.ResultsTRT induced a significant increase in total and free testosterone and estradiol. All IIEF domains significantly improved after TRT. AR CAG repeats negatively and significantly correlated with all the variations (Δ‐) of sexual function domains, except for Δ‐OS. Conversely, Δ‐total testosterone was found to be positively and significantly correlated with sexual function domain variations, except for Δ‐IS and Δ‐OS. Δ‐estradiol did not correlate significantly with any of the variations of sexual function domains. After inclusion in generalized linear models, the number of AR gene CAG triplets was found to be independently and negatively associated with Δ‐EF, Δ‐SD, Δ‐IS, and Δ‐Total IIEF‐15 score, whereas Δ‐total testosterone was independently and positively associated with Δ‐EF, Δ‐OF, Δ‐SD, and Δ‐Total IIEF‐15 score. However, after including time 0 total testosterone in the model, AR gene CAG triplets remained independently and negatively associated only with Δ‐EF and Δ‐Total IIEF‐15 score, whereas Δ‐total testosterone was independently and positively associated only with Δ‐EF.ConclusionsLonger length of AR gene CAG repeat tract seems to lower TRT‐induced improvement of sexual function in LOH. Tirabassi G, Corona G, Biagioli A, Buldreghini E, delli Muti N, Maggi M, and Balercia G. Influence of androgen receptor CAG polymorphism on sexual function recovery after testosterone therapy in late‐onset hypogonadism. J Sex Med 2015;12:381–388. |
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