Inhibitory action of calcitonin gene-related peptide (CGRP) in the mouse colon |
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| Authors: | A Cadieux F Pomerleau S St-Pierre A Fournier |
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| Affiliation: | Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Quebec, Canada. |
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| Abstract: | The effect and mechanism of action of calcitonin gene-related peptide (CGRP) have been investigated on the mouse distal colon. CGRP caused a concentration-dependent relaxation which was not blocked by classical pharmacological antagonists. The response pattern was characterized by a relatively rapid onset and long sustained duration. The results suggest that CGRP itself may contribute to regulating the muscular tone of the mouse colon. |
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