Clinical characteristics of lupus myocarditis in Korea |
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Authors: | Jae-Wook Chung Dai-Yeol Joe Han-Jung Park Hyoun-Ah Kim Hae-Sim Park Chang-Hee Suh |
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Institution: | (1) Department of Allergy and Rheumatology, Ajou University School of Medicine, Woncheon-dong, San5, Youngtong-gu, Suwon, 443-721, South Korea |
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Abstract: | Clinically important myocarditis is an unusual feature in systemic lupus erythematosus (SLE). We describe the clinical characteristics,
management and outcomes of five SLE patients who developed severe left ventricular dysfunction. Four patients were female
with mean age of 36.4 years. Three patients had both lupus myocarditis and lupus nephritis. Four patients had raised anti-dsDNA
antibody titer and low complement level and two patients had positive IgG anticardiolipin antibody. Three patients were treated
by high-dose corticosteroids, one patient by intravenous pulse methylprednisolone, and one patient by intravenous immunoglobulin
and pulse cyclophosphamide with high dose corticosteroids. Left ventricular function improved markedly in four patients and
all of them had no recurrence of lupus myocarditis up to follow-up of 33 months. However, one patient, who showed no improvement
of left ventricular function, was expired due to sudden cardiac arrest. Lupus myocarditis should be treated by immunosuppressive
therapy with high-dose corticosteroids and mostly the prognosis might be good with early treatment. |
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Keywords: | Systemic lupus erythematosus Myocarditis Immunosuppressive therapy |
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