| 实验性帕金森氏病免疫功能变化 |
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| 引用本文： | 李康生,余秀葵.实验性帕金森氏病免疫功能变化[J].现代免疫学,1993,13(1):13-16. |
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| 作者姓名： | 李康生 余秀葵 |
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| 作者单位： | 汕头大学医学院微生物学教研室，汕头大学医学院微生物学教研室，汕头大学医学院微生物学教研室，汕头大学医学院微生物学教研室 广东汕头 515031，广东汕头 515031，广东汕头 515031，广东汕头 515031 |
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| 摘 要： | 实验性帕金森氏病(PD)大鼠动物模型免疫功能变化研究表明,大鼠单侧黑质损毁后第4天,胸腺细胞自发增殖明显降低,脾脏细胞对羊红细胞抗体产生明显增加,自然杀伤(NK)细胞活性增强,胸腺、脾脏淋巴细胞转化无明显变化。体外研究表明,多巴胺(DA)对免疫功能无明显影响。
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| 关 键 词： | 大鼠PD 胸腺细胞增殖 抗体产生 NK活性 |
EXPERIMENTAL PARKINSON'S DISEASE AND ITS IMMUNOLOGICAL STATE |
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| Li Kangsheng Yu Xiukui Yang Mianhua Liu Tiefu.EXPERIMENTAL PARKINSON''''S DISEASE AND ITS IMMUNOLOGICAL STATE[J].Current Immunology,1993,13(1):13-16. |
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| Authors: | Li Kangsheng Yu Xiukui Yang Mianhua Liu Tiefu |
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| Institution: | Li Kangsheng Yu Xiukui Yang Mianhua Liu TiefuDepartment of Microbiology,Shantou University Medical College |
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| Abstract: | An experimental Parkinson's Disease (PD)model was established in Wistar rats by electric destruction of Substantia Nigra (SN). Four days after the destruction, immu- nological status examination of the rats revealed: depressed thymocyte spontaneous proliferation (p<0.05), increased antibody production to SEBC by splenocytes (p< 0.05), enhanced cytotoxicity of natural killer cells (NK) in spleen (p<0.05) but no obvious change in thymocyte and splenocyte proliferation induced by ConA. Dopamine was not found to have direct effects on immune cells in vitro. |
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| Keywords: | Rat PD Thymocyte proliferation Antibody production NK cytoto-xicity |
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