注射用硫酸头孢噻利与6种输液的配伍稳定性考察

目的:考察注射用硫酸头孢噻利与6种输液的配伍稳定性。方法:在25℃下,将注射用硫酸头孢噻利分别与0.9%氯化钠注射液、5%葡萄糖注射液、葡萄糖氯化钠注射液、复方氯化钠注射液、木糖醇注射液、转化糖注射液配伍,在24 h内考察配伍液的外观、pH值、不溶性微粒变化,用高效液相色谱法测定硫酸头孢噻利的含量。结果:硫酸头孢噻利与6种输液配伍在24 h内含量>97%,溶液外观、pH值无明显变化,不溶性微粒符合《中国药典》(2005年版)规定。结论:硫酸头孢噻利与6种输液在25℃、24 h内配伍稳定。

Study on Compatible Stability of Cefoselis Sulfate for Injection in 6 Kinds of Infusions

OBJECTIVE： To study the compatible stability of cefoselis sulfate for injection in 6 kinds of infusions. METHODS： Cefoselis sulfate for injection was mixed with 0.9% Sodium chloride injection, 5% Glucose injection, Glucose sodium chloride injection, Compound sodium chloride, Xylitol injection and invert sugar injection at 25 ℃. The external appearance,pH value and the number of insolubility particles of mixture were observed, and the content of cefoselis sulfate was determined by HPLC. RESULTS： The contents of cefoselis sulfate in six kinds of mixtures were more than 97% within 24 h. Appearance and pH value had no significance change. The number of insolubility particles was also consistent with Chinese Pharmacopeia（2005 edition）. CONCLUSION ： Cefoselis sulfate mixed with 6 kinds of infusions at 25℃ are stable within 24 h.