氨氯地平联合依那普利治疗高血压病左心室舒张功能不全的临床观察

目的:观察氨氯地平联合依那普利治疗高血压病左心室舒张功能不全的临床疗效。方法:2009年3月～2010年3月,我院42例高血压病左心室舒张功能不全患者,采用氨氯地平联合依那普利治疗,观察治疗前后血压、心功能指标的变化,评价临床疗效。结果:氨氯地平联合依那普利治疗高血压病左心室舒张功能不全的临床有效率为90.5%。与治疗前比较,治疗后收缩压、舒张压和脉搏压发生明显下降(P<0.05);E峰、E/A明显增加(P<0.05),A峰、左室后壁舒张末期厚度(LVPWT)和室间隔舒张末期厚度(IVST)明显下降(P<0.05)。结论:对高血压病左心室舒张功能不全患者采用氨氯地平联合依那普利治疗,临床疗效高,不仅能够明显降低血压,还能够改善患者的心功能状态。

Clinical Observation of Amlodipine and Enalapril in the Treatment of Hypertension Left Ventricular Diastolic Dysfunction

OBJECTIVE：To observe the clinical efficacy of amlodipine and enalapril in the treatment of hypertension left ventricular diastolic dysfunction in.METHODS：From Mar.2009 to Mar.2010,42 hypertensive patients with left ventricular diastolic dysfunction received amlodipine and enalapril.The blood pressure,heart function index were observed to evaluate the clinical efficacy.RESULTS：The clinical effective rate of amlodipine and enalapril for hypertension left ventricular diastolic dysfunction was 90.5%.Compared with before treatment,SBP,DBP and PP declined dramatically after treatment（P0.05）;E peak,E/A significantly increased significantly（P0.05）,A peak,LVPWT and IVST significantly decreased（P0.05）.CONCLUSION：Combination therapy of amlodipine and enalapril is effective for hypertensive left ventricular diastolic dysfunction.It not only can significantly lower blood pressure,also can improve heart function in patients.It is worthy of spreading in the clinic.