| 正交试验优选香桂化浊胶囊中挥发油的包合工艺 |
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| 引用本文： | 刘红淼,姜少灏,张振杰,杨继章.正交试验优选香桂化浊胶囊中挥发油的包合工艺[J].中国药房,2010(47):4449-4450. |
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| 作者姓名： | 刘红淼 姜少灏 张振杰 杨继章 |
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| 作者单位： | [1]河北医科大学第一医院,石家庄市050031 [2]河北医科大学,石家庄市050017 |
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| 基金项目： | 河北省中医药管理局科研计划课题资助项目（2010009） |
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| 摘 要： | 目的:优选β-环糊精包合香桂化浊胶囊中广藿香与肉桂中混合挥发油的工艺条件。方法:采用L(934)正交设计,以挥发油的包合率为评价指标,考察挥发油与β-环糊精比例、包合温度、搅拌时间3个因素对包合工艺的影响。结果:最佳工艺条件为挥产发。油与β-环糊精比例为1∶5(mL∶g),包合温度为60℃,搅拌时间为60min。结论:所优选的工艺方法简单、效率高,适合工业化生
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| 关 键 词： | 香桂化浊胶囊 挥发油 β-环糊精 正交设计 包合 |
Optimization of the Inclusion Technology of Volatile Oil from Xianggui Huazhuo Capsule by Orthogonal Experiment |
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| LIU Hong-miao,ZHANG Zhen-jie,YANG Ji-zhang.Optimization of the Inclusion Technology of Volatile Oil from Xianggui Huazhuo Capsule by Orthogonal Experiment[J].China Pharmacy,2010(47):4449-4450. |
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| Authors: | LIU Hong-miao ZHANG Zhen-jie YANG Ji-zhang |
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| Institution: | (The First Hospital of Hebei Medical University, Shijiazhuang 050031, China) JIANG Shao-hao(Hebei Medical University, Shijiazhuang 050017, China) |
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| Abstract: | OBJECTIVE： To optimize β-cyclodextrin inclusion technology of volatile oil compounds of Pogostemon cablin and Cinnamomum cassia in Xianggui huazhuo capsule. METHODS： Orthogonal design was used to investigate influence effect of the ratio of the volatile oil to β-cyclodextrin, the temperature for clathration and the duration of stirring as three factors on inclusion technology with inclusion rate of volatile oil as index. RESULTS： The optimized inclusion condition was as follows： the ratio of volatile oil to β-cyclodextrin was 1 ∶ 5（mL ∶ g）, the temperature for clathration was 60 ℃,and the duration of stirring was 60 min. CONCLUSION： The optimized technology is simple, efficient, and suitable for industrial production. |
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| Keywords: | Xianggui huazhuo capsule Volatile oil β-cyclodextrin Orthogonal design Inclusion |
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