硫酸沙丁胺醇联合布地奈德雾化吸入治疗哮喘急性发作的临床观察

目的:观察硫酸沙丁胺醇联合布地奈德混悬液雾化吸入治疗哮喘急性发作的临床疗效。方法:采用随机对照分组研究方法,将78例哮喘急性发作患者随机分为观察组与对照组,各39例。2组均采用抗炎、吸氧、吸痰、镇静、维持水电解质平衡、纠正酸碱紊乱、补液等对症治疗。对照组在上述基础上加用硫酸沙丁胺醇(雾化液,1.25mg)雾化吸入治疗。观察组在对照组基础上加用布地奈德(混悬液,0.5～1mg)雾化吸入治疗。结果:观察组症状、体征平均消失时间明显短于对照组,2组比较差异有统计学意义(P<0.05)。结论:硫酸沙丁胺醇联合布地奈德雾化吸入是治疗哮喘急性发作的较好方法,在改善症状、缩短病程、提高疗效方面显著优于对照组,且未见任何不良反应。

Clinical Observation of Aerosol Inhalation of Albuterol Sulfate and Budesonide in the Treatment of Acute Asthma

OBJECTIVE：To observe the clinical effect of aerosol inhalation of albuterol sulfate and budesonide in the treatment of acute asthma.METHODS：In randomized controlled study,78 cases of acute asthma were divided into two groups averagely,i.e.observation group and control group（39 cases）.Both groups received the treatment of anti-inflammatory,oxygen uptake,and sputum suction,sedation,maintaining water and electrolyte balance,correcting acid-based disorders and fluid replacement.Control group was additionally given albuterol sulfate（atomized liquid,1.25 mg）.On the basis of control group,observation group was additionally given aerosol inhalation of budesonide（suspension,0.5～1 mg）.RESULTS：The average time for symptoms and sign to disappear in observation group was obviously shorter than in control group.There was statistical significance（P〈0.05）.CONCLUSION：The aerosol inhalation of albuterol sulfate and budesonide is a good method in the treatment of acute asthma.It is better than albuterol sulfate alone for acute asthma effectiveness in improving symptoms and clinical efficacy,shortening the duration of illness.No adverse drug reaction was found during treatment.So it could be commonly applied in the treatment of acute asthma.