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纳洛酮治疗新生儿缺氧缺血性脑病
引用本文:许平,马桂荣,吕学云,张勇军,丁登森,任家明.纳洛酮治疗新生儿缺氧缺血性脑病[J].中国新药与临床杂志,1994(2).
作者姓名:许平  马桂荣  吕学云  张勇军  丁登森  任家明
作者单位:山东省聊城地区人民医院
摘    要:新生儿缺氧缺血性脑病62例,分2组。纳洛酮组31例(男性20例,女性11例)采用常规综合治疗外加用纳洛酮0.2mg于10%葡萄糖溶液100mL中静脉滴注,隔1h可重复,每日2-3次,共用5-7d。对照组采用相同的常规综合治疗,疗程相同。结果:纳洛酮组治愈率87%,病死率13%,对照组依次为68%和32%;组间比较P<0.05。未发生不良反应。

关 键 词:纳洛酮,新生儿窒息,脑缺血

Naloxone in treating hypoxic-ischemic encephalopathy
XU Ping,MA Gui-Rong,LU Xue-Yun,ZHANG Yong-Jun,DING Deng-Sen,REN Jia-Ming.Naloxone in treating hypoxic-ischemic encephalopathy[J].Chinese Journal of New Drugs and Clinical Remedies,1994(2).
Authors:XU Ping  MA Gui-Rong  LU Xue-Yun  ZHANG Yong-Jun  DING Deng-Sen  REN Jia-Ming
Abstract:Thirty-one neonates(M 20,F11)with hypoxic-ischemic encephalopathy were given naloxone 0.2 mg in 10% glucose solution 100 mL,iv every hour,twice or three times a day,for 5-7 d as a course in addition to conventional therapy.Another 31 neonates(M 21,F 10) were given routine remedies as control.Results showed that the cure rate and mortality of naloxone group were 87% and 13%;that the control group were 68% and 32%,respectively(P<0.05).No adverse reaction was observed.
Keywords:naloxone  asphyxia neonatorum  cerebral ischemia  
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