| 改良大鼠腹部心移植模型的制作 |
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| 引用本文： | 余思,何晓顺,马毅.改良大鼠腹部心移植模型的制作[J].北京大学学报(医学版),2008,40(3):327-329. |
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| 作者姓名： | 余思 何晓顺 马毅 |
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| 作者单位： | (中山大学1.附属第六医院胃肠外科,广州 510655;2.附属第一医院器官移植科) |
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| 基金项目： | 美国中华医学会资助项目 |
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| 摘 要： | 目的:总结制作大鼠腹部心脏移植模型的技巧并改良此模型的制作方法.方法:对传统Ono术式的受体准备、供心切取、供心移植等环节进行改良,建立Wistar和SD大鼠的腹部异位心脏移植模型.结果:共完成100例大鼠腹部心脏移植术,90例成功,手术成功率90%.结论:与传统0n0术式相比,此改良术式缩短供心冷缺血时问和腹主动脉阻断时间,降低吻合难度,提高手术成功率,是一种稳定、可靠的大鼠腹部心脏移植模型.
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| 关 键 词： | 心脏移植 模型 动物 大鼠 |
| 文章编号： | 1671-167X(2008)03-0327-03 |
| 修稿时间： | 2007年12月28 |
Establishment of modified abdominal heart transplantation model in rats |
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| YU Si,HE Xiao-shun,MA Yi.Establishment of modified abdominal heart transplantation model in rats[J].Journal of Peking University:Health Sciences,2008,40(3):327-329. |
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| Authors: | YU Si HE Xiao-shun MA Yi |
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| Institution: | Department of Gastroenterology, The 6th Affiliated Hospital, Guangzhou, China. yusi1976111@yahoo.com.cn |
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| Abstract: | OBJECTIVE: To investigate the techniques of establishment of abdominal heart transplantation model in rats and modify the procedure to make it more stable and improve the success rate. METHODS: Heterotopic abdominal heart transplantations of Wistar and SD rats were performed by using Ono's method with modification of preparation of recipients, donor cardiectomy and donor transplantations. RESULTS: One hundred heart transplantations were performed, among which 90 were successful. The success rate was 90%. CONCLUSION: This modified Ono's method can shorten the ischemia time and recipient abdominal aorta occlusion time, make vessel anastomosis easier and increase the success rate of operation. It is a stable and reliable model of heart transplantations in rats. |
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| Keywords: | Heart transplantation Models animal Rats |
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