2005-2008年铜绿假单胞菌耐药情况变迁分析

目的分析2005~2008年临床分离的铜绿假单胞菌耐药性的变迁，为铜绿假单胞菌感染的临床治疗提供依据。方法采用纸片法测定临床分离到共1119株铜绿假单胞菌对12种抗菌药物的敏感性。结果铜绿假单胞菌对大多数抗生素的耐药性均呈现上升趋势，目前首选药物仍然是碳青霉烯类，其对亚胺培南的敏感性为71.3%（2008年）。4年中，铜绿假单胞菌感染发生率在干部科、ICU呈上升趋势。结论铜绿假单胞菌是医院内感染的重要致病菌，对铜绿假单胞菌引起的感染应尽早进行病原学检查，选择合适的抗菌药物。

Changes of Drug - resistance of Pseudomonas Aeruginosa During 2005 - 2008

ObjectiveTo analyze the antibiotic resistance of Pseudomonas aeruginosa（PA） and provide useful reference for clinical tretment of PA. MethodsSusceptibility rates of 12 antibiotics against 1119 strains of PA were determined by K-B method. ResultsThe resistante of PA to 12 antibiotics was increased in 2005~2008. The resistant to imipenem was 71.3% in 2008,so carbepenem was the first choice to treat the infection of PA. The infection caused by PA happened more and more in department for Cadre and Intensice Care Units（ICU） during the past four years. ConclusionPA has been one of the important pathogen in hostipal infection. The pathogen should be isolated as early as possible when PA infection is suspected. Antibiotic therapy for PA infection should be selected appropriately.