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Analysis of factors affecting uptake of Tc-99m Sn-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma |
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| Authors: | Yoshihisa Hasegawa Shunichi Nakano Tomotaka Sobue Makoto Fujita Shingo Ishiguro Yo Sasaki Shingi Imaoka Sachiko Tanaka Hiroshi Kasugai Atsuo Inoue Jyunnosuke Kojima |
| Institution: | 1. Department of Nuclear Medicine, The Center for Adult Diseases, Osaka, 3-3, Nakamichi-1-chome Higashinari-ku, 537, Osaka, Japan 2. Department of Field Research, The Center for Adult Diseases, Osaka 3. Department of Radiology, The Center for Adult Diseases, Osaka 4. Department of Pathology, The Center for Adult Diseases, Osaka 5. Department of Surgery, The Center for Adult Diseases, Osaka 6. Department of Innternal Medicine, The Center for Adult Diseases, Osaka |
| Abstract: | We performed Tc-99m PMT imaging in 176 patients with HCC and evaluated factors affecting99mTc-PMT uptake by HCC with a logistic model. The probability of HCC showing increase in uptake of the radioisotope was 104.6 times higher in patients with the Ed I type than in those with the Ed III type and 12.1 times higher in patients with a tumor diameter of 5.0–7.9 cm than in those with a tumor diameter of 2.0–5.0 cm. Among the other variables, the serum AFP level and sex were suggested to have effects similar to those of the tumor size on Tc-99m PMT uptake by HCC. The grade of morphological differentiation of the tumor was therefore most markedly related to Tc-99m PMT uptake. |
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