| 左氧氟沙星凝胶的制备及质量控制 |
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| 引用本文： | 瞿天莉,蒋卉.左氧氟沙星凝胶的制备及质量控制[J].中国药师,2005,8(10):840-841. |
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| 作者姓名： | 瞿天莉 蒋卉 |
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| 作者单位： | 南京医科大学第一附属医院,南京,210029 |
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| 摘 要： | 目的:制备左氧氟沙星凝胶剂并制定质控标准.方法:以卡波姆940为基质,三乙醇胺为中和剂制成凝胶剂;采用反相高效液相色谱法测定凝胶中左氧氟沙星的含量.结果:含量测定线性回归方程为A=7.51×104C 3.71×104(r=0.999 9),线性范围4.0～20μg·ml-1.平均回收率99.7%,RSD0.57%.结论:该凝胶剂处方合理,质量稳定,适于临床应用.
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| 关 键 词： | 左氧氟沙星 凝胶剂 制备 质量控制 |
| 文章编号： | 1008-049X（2005）10-0840-02 |
| 收稿时间： | 2004-11-12 |
| 修稿时间： | 2005-06-22 |
The Preparation and Quality Control of Levofloxacin Gel |
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| Qu Tianli,Jiang Hui.The Preparation and Quality Control of Levofloxacin Gel[J].China Pharmacist,2005,8(10):840-841. |
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| Authors: | Qu Tianli Jiang Hui |
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| Abstract: | Objective: To study preparation and quality control of levofloxacin gel. Method: Carbopol-940 was used as base and triethanolamine was used as neutralizer to prepare the levofloxacin gel. RP-HPLC was used to determine the content of levofloxacin in the gel. Result: The gel was of good capability and steady quality. The content determination method was simple and rapid. The average recovery was 99.7% (RSD =0.57% ). Conclusion: The formulation of the gel is reasonable,the quality is safe, steady and suitable for clinical use. |
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| Keywords: | Levofloxaein Gel Preparation Quality control |
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