A lasting change in protein phosphorylation associated with septal kindling

Male Holtzman rats stimulated through a right medial septal electrode displayed prominent hippocampal afterdischarges and the progressive development of kindled seizures. Hippocampal synaptic plasma membranes of kindled rats showed a reduction of³²P incorporation into a protein of approximately 50,000 daltons. This change was not present in controls that received twice as many stimulations as kindled rats with a timing that did not lead to kindling. In kindled rats, reduction of³²P incorporation persisted at least 2 months without further stimulation.