| 快速制备自体肿瘤浸润淋巴细胞联合白细胞介素2胸腔输注治疗癌性胸腔积液 |
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| 引用本文： | 刘宝瑞,邹征云,钱晓萍,王燕,杜娟,胡文静,殷海涛,孔炜伟,王立峰,李丽,陈蓉.快速制备自体肿瘤浸润淋巴细胞联合白细胞介素2胸腔输注治疗癌性胸腔积液[J].医学研究生学报,2007,20(8):833-835. |
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| 作者姓名： | 刘宝瑞 邹征云 钱晓萍 王燕 杜娟 胡文静 殷海涛 孔炜伟 王立峰 李丽 陈蓉 |
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| 作者单位： | 南京大学医学院附属南京市鼓楼医院肿瘤中心,江苏南京,210008 |
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| 基金项目： | 江苏省南京市医学科技发展计划 |
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| 摘 要： | 目的：研究体外快速制备的自体肿瘤浸润淋巴细胞（TIL）联合白细胞介素2（IL-2）疗法对癌性胸腔积液的治疗作用.方法：对2003年8月至2004年11月间确诊的22例癌性胸腔积液患者,采用该作者实验室建立的胸腔积液TIL体外快速制备技术制备TIL,胸腔输注,后续胸腔内灌注IL-2,每天100万单位,连续4d为1治疗周期,观察其疗效和不良反应.结果：采用该疗法治疗1个周期,22例患者中8例完全缓解（36.4%）,11例部分缓解（50.0%）,3例无效（13.6%）,总有效率达86.4%.有效的病例随访中均未见治疗侧胸腔积液复发或增加;除极少数患者治疗中出现低热和胸痛外,未见有其他不良反应发生.结论：自体TIL联合IL-2治疗癌性胸腔积液,具有良好的临床应用价值.
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| 关 键 词： | 癌性胸腔积液 肿瘤浸润淋巴细胞 白细胞介素2 |
| 文章编号： | 1008-8199（2007）08-0833-03 |
| 收稿时间： | 2005-10-20 |
| 修稿时间： | 2006-04-24 |
Therapeutic effect of tumor infiltrating lymphocyte plus interleukin-2 intrapleural injection on advanced cancer patients with malignant pleural effusion |
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| LIU Bao-rui,ZOU Zheng-yun,QIAN Xiao-ping,WANG Yan,DU Juan,HU Wen-jing,YIN Hai-tao,KONG Wei-wei,WANG Li-feng,LI Li,CHEN Rong.Therapeutic effect of tumor infiltrating lymphocyte plus interleukin-2 intrapleural injection on advanced cancer patients with malignant pleural effusion[J].Bulletin of Medical Postgraduate,2007,20(8):833-835. |
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| Authors: | LIU Bao-rui ZOU Zheng-yun QIAN Xiao-ping WANG Yan DU Juan HU Wen-jing YIN Hai-tao KONG Wei-wei WANG Li-feng LI Li CHEN Rong |
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| Institution: | Center of Cancer,Drum Tower Hospital,School of Medicine ,Nanjing University,Nanfing 210008,Jiangsu,China |
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| Abstract: | Objective: To study the clinical effects of tumor infiltrating lymphocyte(TIL) plus interleukin-2(IL-2) intrapleural injection on malignant pleural effusion.Methods:22 patients with malignant pleural effusion received TIL plus IL-2 therapy for one course.Results:Pleural effusion disappeared completely in 8 of 22 patients,decreased by more than 50% in volume in 11 patients.Response rate in the study was 86.4%.Performance status improved in 19 patients.No serious side effects were observed,and no recurrence or increase of hydrothorax was observed in the follow up of CR or PR.Conclusion:The protocol of TIL plus IL-2 described here deserved for clinical application. |
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| Keywords: | Malignant pleural effusion Tumor infiltrating lymphocyte Interleukin-2 |
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