防己茯苓汤抗炎镇痛作用的实验研究

目的:研究防己茯苓汤的抗炎镇痛作用。方法:采用热板法、醋酸扭体法镇痛实验模型,二甲苯致小鼠耳肿胀、大鼠毛细血管通透性、大鼠棉球肉芽肿、大鼠蛋清性关节炎、大鼠炎性组织中PGE2含量等炎症模型,研究防己茯苓汤的抗炎镇痛作用。结果:动物实验表明防己茯苓汤对二甲苯、蛋清所致急性炎症有明显抑制作用,能降低大鼠的毛细血管通透性,抑制棉球肉芽肿增生,提高小鼠痛阈值,减少醋酸所致小鼠扭体次数,并能显著降低炎症组织中PGE2的含量。结论:将防己茯苓汤用于抗炎镇痛作用的研究,发现其确有明显的抗炎镇痛作用,并能显著降低炎症组织中PGE2的含量。

Studies on the Anti-inflammatory and Analgesic Actions of Fangji Fuling Decoction

Objective:To investigate the anti-inflammatory and analgesic actions of Fangji Fuling Decoction(FFD).Methods:Analgesic action of FFD was observed by hot-plate method and acetic-acid-induced body twist method.Anti-inflammatory action of FFD was observed on the models of xylene-induced auricular swelling in mice,celiac capillary permeability in rats,cotton-induced granuloma in rats,albumen-induced arthritis and the content of PGE2 in the inflammatory tissue of rats.Results:FFD inhibited the acute inflammation induced by albumen and xylene,decreased the celiac capillary permeability,inhibited the proliferation of granuloma,increased the pain thresh-old in mice and reduced the frequencies of body twist induced by acetic acid,and could decrease the content of PGE2 in the inflammatory tissue significantly.Conclusion:The study of anti-inflammatory and analgesic action of FFD,obviously observe the ability of the anti-inflammatory and analgesic action of this decoction,and it can significantly decrease the content of PGE2 in the inflammatory tissue.