海洛因依赖者工作记忆、执行功能的对照研究

目的 :研究海洛因对工作记忆、执行功能的影响。方法 :对 36例海洛因依赖者和 36例正常对照进行工作记忆和执行功能测试 ,包括常识、算术、数字广度 (顺背 ,倒背 )、逻辑记忆 (即刻、延迟 )、视觉记忆 (即刻视觉再生、延迟视觉再生 )、词汇流畅、数字符号、划痕实验 (A、B)、威斯康星卡片分类实验 (WCST)。结果 :海洛因依赖组在常识、算术、数字广度 (顺背、倒背 )、视觉记忆、划痕实验 (A)测验成绩差于正常对照 ,威斯康星卡片分类实验的持续错误数大于对照而分类个数少于对照组 ,两组比较有显著的统计学差异 (P <0 0 5 )。结论 :海洛因依赖者工作记忆、执行功能存在一定程度损害 ,在康复治疗中应注意采取针对认知损害的康复治疗措施。

A Controlled Study of Working Memory and Executive Function in Heroin Addicts

Objective:To investigate the effect of heroin on working memory(WM)and executive functions(EF)in heroin addicts.Method:WM and EF of heroin addicts(n=36)and normal controls(n=36)were assessed with a battery of neurocognitive evaluation instruments,which includes information,arithmetic,digit span(forward,backward),logical memory(immediate and delayed)visual reproduction(immediate and delayed),verbal fluency test digit symbol,trail making(A,B),and Wisconsin card sorting test(WCST).Result:In contrast to the normal control,the objects had poor performance on information,arithmetic,digit span(forward,backward),visual reproduction(immediate and delayed),trail making(A),and had higher perseverative errors and lower categories number of WCST than the controls(P<0.05).Conclusion:There were certain dysfunctions of WM and EF in heroin addicts,and certain measures should be taken in order to ameliorate it in the course of medical treatment.