某大学新生乙肝表面抗原抗体及转氨酶检测分析

目的调查某高校新生乙型肝炎病毒（HBV）感染情况及对乙型肝炎疫苗的免疫接种情况，结合转氨酶分析HBV感染者的肝功能情况。方法应用乙型肝炎表面抗原（HBsAg）、乙型肝炎病毒表面抗体（HBsAg）快速胶体金法检测北京某高校2007年度7370名新生的HBsAg和HBsAb，同时利用全自动生化分析仪检测血清谷丙转氨酶（ALT）。结果HBsAg阳性检出率为3．3％，本科生与博士生研究生之间差异具有统计学意义（P〈0．01），男生与女生之间差异具有统计学意义（P〈0．01）；HBsAg阳性率为72．0％；ALT（ALT≥60IU／L为异常）在所有新生中异常率为6．1％，在HBsAg阳性与HBsAb阴性同学之间差异有统计学意义（P〈0．01）。结论对高校新生应加强传染病相关知识的宣传，继续加强乙型肝炎疫苗的接种。预防HBV的传播。

Investigation on infection of Hepatitis B virus and liver function in students of a university

Objective To investigate the infection of hepatitis B virus and the HBV vaccine inoculation status, and analyze the liver function of HBsAg positive students with aminotransferase （ALT） test. Methods The rapid colloid gold method was used to detect HBsAg and HBsAb in 7 370 students from a university in Beijing in 2007. ALT was detected by automatic biochemical analyzer. Results The HBsAg positive rate was 3.3 %, and significant differences were found in HBsAg positive rates between bachelor and doctoral students, P 〈 0.01, and between male and female students P 〈 0.01. The HBsAb positive rate was 72.0 %. The abnormal ALT percentage （ALTO60 IU/L） was 6.1%. There was a significant difference between HBsAg positive and negative students, P 〈 0.01. Conclusions It is important to enhance the health education on communicable diseases and enhance the inoculation of HBV vaccine to prevent the spread of HBV.