头颈耳鼻咽喉部原发性结外非霍奇金淋巴瘤临床和免疫组化特征

目的：探讨头颈耳鼻咽喉部原发性结外非霍奇金淋巴瘤(PE-NHL)的临床及免疫表型特征。方法：回顾性分析155例头颈耳鼻咽喉部PE—NHL患者的临床资料，采用免疫组织化学技术复阅病理片改变。结果：临床表现原发器官缺乏特异性，体征以肿块或溃烂型最多。细胞免疫表型结果显示，来源于T细胞者占46．4％，来源于B细胞者占53．6％。其中鼻腔鼻窦以T细胞淋巴瘤为主，韦氏环则以B细胞淋巴瘤为多。结论：头颈耳鼻咽喉部PE-NHL临床过程复杂，特征缺乏特异性，诊断较难。对本病提高警惕，对可疑者反复活检，依据病理学和免疫组织化学改变结合临床特征可确诊。

Analysis on clinical and immunohistochemical characteristics of primary extranodular non-Hodgkin''''s lymphoma in otolaryngol head and neck

Objective:To study the characteristic of clinical manifestation and cell immunophenotype in cases with primary extra nodular non Hodgkin's lymphoma (PE NHL) in otolaryngol head and neck for early diagnosis and treatment.Method:Clinical manifestation of one hundred and fifty five patients with PE NHL in otolaryngol head and neck from 1991 to 2000 were analyzed and restudied by pathological sections with immunohistochemical technology.Result:The age of twenty six to fifty years old was the most common age range in the group of patients with PE NHL.Waldeyer's ring was the most commonly involved site (92 cases ),the rest were in sinonasal (57 cases), in laryngopharynx (2 caes) and in larynx (4 cases). There were no characteristic symptoms of primary lesion located.The lump or fester signs were mostly observed on primary position .Cell immunophenotype result displayed 46.4 % of the PE NHL originating from T cells, while 53.6 % originating from B cell .Most of waldeyer's PE NHL originating from B cell, while most of sinonasal PE NHL originating from T cell.Conclusion:The clinical behavior in patients with the PE NHL is complicated and lacks characterisic symptoms, so the diagnosis is difficult.Doctor should be alert and the repeated exact biopsy may be needed.The diagnosis can be definite by pothological and immunohistochemical approaches with clinical manifestation.