Magnetic resonance imaging and histopathology of cerebral gliomas |
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Authors: | M Watanabe R Tanaka N Takeda |
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Institution: | (1) Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan |
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Abstract: | Summary The correlation of magnetic resonance imaging (MRI) with histopathological findings was analysed in 26 patients with untreated cerebral gliomas. In low-grade gliomas, T2-weighted images demonstrated relatively homogeneous high-intensity lesions involving both the grey and the white matter. In high-grade gliomas, especially grade IV, T2-weighted images demonstrated prominent heterogeneity in signal intensity, which consisted of a hyperintense core, less hyperintense or normal intensity rim and surrounding finger-like areas of high intensity. Marked and irregular contrast enhancement was evident in all but one case of these high-grade gliomas in which gadolinium-DTPA was used. Histological examination revealed tumour cells extending as far as the borders of the high-intensity areas shown on T2-weighted images in both high-and low-grade gliomas, but in 5 of 8 low-grade and 4 of 18 high-grade gliomas, isolated tumour cells extended beyond the hyperintense areas shown on T2-weighted images. |
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Keywords: | Cerebral glioma Histopathology Magnetic resonance imaging Gadolinium-DTPA |
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