Synthesis and antimicrobial evaluation of some new cyclooctanones and cyclooctane-based heterocycles |
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Authors: | Ali Korany A Hosni Hanaa M Ragab Eman A El-Moez Sherein I Abd |
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Affiliation: | Applied Organic Chemistry Department, National Research Center, Dokki-Cairo, Egypt. kornykhlil@yahoo.com |
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Abstract: | The versatile synthon (E)-2-((dimethyl amino)methylene)cyclooctanone (2) was used as a key intermediate for the synthesis of cyclooctanones and cyclooctane-based heterocycles with pyrazole, isoxazole, pyrimidine, pyrazolopyrimidine, triazolopyrimidine and imidazopyrimidine derivatives via its reactions with several nitrogen nucleophiles. The newly synthesized compounds were screened in vitro for their antimicrobial activity against pathogenic microorganisms (Listeria monocytogenes, methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans). Most of the tested compounds showed moderate to high antibacterial and antifungal effects against the tested pathogenic microorganisms. Among the synthesized compounds, 2-((p-sulfonamidophenyl)methylene)cyclooctanone (5) showed excellent activity against Listeria monocytogenes. |
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Keywords: | Cyclooctanone Pyrazole Pyridine Pyrimidine Listeria monocytogenes Methicillin‐resistant Staphylococcus aureus (MRSA) |
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