酒精性肝硬化患者细胞因子改变的临床研究

目的探讨细胞因子在酒精性肝硬化发病机制中的作用。方法对酒精性肝硬化代偿期和失代偿期患者及健康者用放射免疫分析法检测细胞因子的含量进行分析。结果代偿期IL-6升高,差异有统计学意义（P〈0.01）,IL-10下降,差异有统计学意义（P〈0.05）;失代偿期IL-10无明显变化,差异无统计学意义（P〉0.05）,TGFβ、IL-6、IL-8、TNFα均升高,差异有统计学意义（P〈0.01）。结论酒精性肝硬化患者随着病情加重,细胞因子IL-6、IL-8、TNFα、TGFβ逐渐升高,IL-10无明显改变,对疾病的诊断及治疗有一定的指导作用。

The serum cytokine level in alcoholic liver cirrhosis patients

Objective To study the serum cytokine level in patients with alcoholic liver cirrhosis. Methods The changes in serum cytokine level in compensated and decompensated alcoholic liver cirrhosis patients and healthy controls were measured by radioimmunoassay technique. Results The serum level of IL-6 increased and IL-10 decreased in compensated alcoholic cirrhosis patients whereas the levels of IL-6,TNF-α,IL-8 and TGF-β were increased in decompensated alcoholic liver cirrhosis patients.Conclusion The serum levels of IL-6,IL-8,TNF-α and TGF-β increased gradually with disease progress. Monitoring the serum cytokine levels change in compensated and decompensated alcoholic liver cirrhosis is helpful in disease prognosis.