| 健脾活血方胃安散对PLGC模型大鼠p53和p16基因表达的影响 |
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| 引用本文： | 刘洪,李志涛,贾艳敏,赵双梅,李慧臻.健脾活血方胃安散对PLGC模型大鼠p53和p16基因表达的影响[J].辽宁中医药大学学报,2013(3):28-29. |
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| 作者姓名： | 刘洪 李志涛 贾艳敏 赵双梅 李慧臻 |
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| 作者单位： | 天津中医药大学第二附属医院消化科 |
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| 基金项目： | 天津市教委科研基金项目(020334) |
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| 摘 要： | 目的：研究健脾活血方胃安散对胃癌前病变模型大鼠p53和p16基因表达的影响，以进-步探求其发病机制方法：采用改进以N-甲基-N’硝基-N-亚硝基胍（MNNG）为基础的联合造模方案造成胃癌前期病变大鼠模型，免疫组化方法观察胃黏膜p53、p16基因的表达。结果：p53免疫组化染色结果提示各组均为阴性表达；p16染色在表达率及表达强度方面，均有-定程度提高。其调节p16基因表达的作用与胃复春组比较具有显著性差异。结论：健脾活血方胃安散可提高抑癌基因p16表达，具有-定的预防胃癌前病变发展成胃癌的作用。
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| 关 键 词： | 胃安散 胃癌前病变 p53 p16 |
Effect of Jianpi Huoxue Recipe(Weian Powder) on Expressions of p53 and p16 in Rat Models with Precancerous Lesions of Gastric Cancer(PLGC) |
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| LIU Hong,LI Zhitao,JIA Yanmin,ZHAO Shuangmei,LI Huizhen.Effect of Jianpi Huoxue Recipe(Weian Powder) on Expressions of p53 and p16 in Rat Models with Precancerous Lesions of Gastric Cancer(PLGC)[J].Journal of Liaoning University of Traditional Chinese Medicine,2013(3):28-29. |
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| Authors: | LIU Hong LI Zhitao JIA Yanmin ZHAO Shuangmei LI Huizhen |
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| Institution: | (Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China) |
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| Abstract: | Ohjective： To research the effect ofJianpi Huoxue Recipe （ Weian Powder ） on expressions of p53 and p16 in rat models with PLGC, in order to explore its pathogenesis. Methods：Rat models were established with PI,GC by using MNNG-hased joint modeling program; the expressions of p53 and p16 on gastric mueosa were observed by immunohistochemistry. Results ： The results of p53 immune histoehemical staining were all negative; expression rate and intensity of p 16 staining had a certain degree of improvement. In regulating the expression of P16,Weian Powder had a significant difference compared with Weifuehun. Conclusion ： Jianpi Huoxue Reeipe（ Weian Powder ） can increase the expression of tumor suppressor gene p 16, and has the effect to prevent PLGC into gastric cancer. |
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| Keywords: | Weian Powder PLGC p53 p16 |
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